Organization
School of Medicine (Life Sciences and Social Medicine) Department of Microbiology Assistant Professor
Title
Assistant Professor
Contact information
FUKAMI Shin-ichi
Degree
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博士（医学） ( 2003.3 東京大学 )
Research Interests
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differentiation
Research Areas
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Life Science / Neuroscience-general
Research History
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Fukushima Medical University School of Medicine (Clinical Medicine) Department of Hematology Assistant Professor
2020.4 - Now
Papers
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The suppressive effects of Mer inhibition on inflammatory responses in the pathogenesis of LPS-induced ALI/ARDS.
Fukatsu M, Ohkawara H, Wang X, Alkebsi L, Furukawa M, Mori H, Fukami M, Fukami S-I, Sano T, Takahashi H, Harada-Shirado K, Kimura S, Sugimoto K, Ogawa K, Ikezoe T
Science Signaling 150 ( 724 ) 2533 2022.3
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Developmental dysregulation of excitatory-to-inhibitory GABA-polarity switch may underlie schizophrenia pathology: A monozygotic-twin discordant case analysis in human iPS cell-derived neurons
Michihiro Toritsuka, Hiroki Yoshino, Manabu Makinodan, Daisuke Ikawa, Sohei Kimoto, Kazuhiko Yamamuro, Kazuya Okamura, Wado Akamatsu, Yohei Okada, Takuya Matsumoto, Kazumichi Hashimoto, Yoichi Ogawa, Yasuhiko Saito, Kyosuke Watanabe, Chieko Aoki, Ryohei Takada, Shin-ichi Fukami, Kaori Hamano-Iwasa, Hideyuki Okano, Toshifumi Kishimoto
Neurochemistry International 150 105179 - 105179 2021.11（ ISSN:0197-0186 ）
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Developmental dysregulation of excitatory-to-inhibitory GABA-polarity switch may underlie schizophrenia pathology: A monozygotic-twin discordant case analysis in human iPS cell-derived neurons
Michihiro Toritsuka, Hiroki Yoshino, Manabu Makinodan, Daisuke Ikawa, Sohei Kimoto, Kazuhiko Yamamuro, Kazuya Okamura, Wado Akamatsu, Yohei Okada, Takuya Matsumoto, Kazumichi Hashimoto, Yoichi Ogawa, Yasuhiko Saito, Kyosuke Watanabe, Chieko Aoki, Ryohei Takada, Shin-ichi Fukami, Kaori Hamano-Iwasa, Hideyuki Okano, Toshifumi Kishimoto
Neurochemistry International 150 105179 - 105179 2021.11（ ISSN:0197-0186 ）
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Developmental dysregulation of excitatory-to-inhibitory GABA-polarity switch may underlie schizophrenia pathology: A monozygotic-twin discordant case analysis in human iPS cell-derived neurons.
Toritsuka M, Yoshino H, Makinodan M, Ikawa D, Kimoto S, Yamamuro K, Okamura K, Akamatsu W, Okada Y, Matsumoto T, Hashimoto K, Ogawa Y, Saito Y, Watanabe K, Aoki C, Takada R, Fukami SI, Hamano-Iwasa K, Okano H, Kishimoto T
Neurochemistry International 150 105179 2021.9
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Effects of the mode of re-socialization after juvenile social isolation on medial prefrontal cortex myelination and function.
Makinodan M, Ikawa D, Yamamuro K, Yamashita Y, Toritsuka M, Kimoto S, Yamauchi T, Okumura K, Komori T, Fukami S-i, Yoshino H, Kanba S, Wanaka A, Kishimoto T
Scientific Reports 7 ( 2 ) 5481 2017.7
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Microglia-derived neuregulin expression in psychiatric disorders.
Ikawa D, Makinodan M, Iwata K, Ohgidani M, Kato TA, Yamashita Y, Yamamuro K, Kimoto S, Toritsuka M, Yamauchi T, Fukami S-i, Yoshino H, Okumura K, Tanaka T, Wanaka A, Owada Y, Tsujii M, Sugiyama T, Tsuchiya K, Mori N, Hashimoto R, Matsuzaki H, Kanba S, Kishimoto T
Brain, Behavior, and Immunity 61 375 - 385 2017.3
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Social isolation impairs remyelination in mice through modulation of IL-6.
Makinodan M, Ikawa D, Miyamoto Y, Yamauchi J, Yamamuro K, Yamashita Y, Toritsuka M, Kimoto S, Okumura K, Yamauchi T, Fukami S-i, Yoshino H, Wanaka A, Kishimoto T.
The FASEB Journal 30 ( 12 ) 4267 - 4274 2016.12
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Primary cerebral and cerebellar astrocytes display differential sensitivity to extracellular sodium with significant effects on apoptosis.
Takeda T, Makinodan M, Fukami S-i, Toritsuka M, Ikawa D, Yamashita Y, Kishimoto T
Journal of Cellular Biochemistry 32 ( 4 ) 395 - 400 2014.6
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喫煙と神経細胞
深見 伸一, 岸本 年史
最新精神医学 16 ( 4 ) 453 - 457 2011.7
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Identification of a novel intronic enhancer responsible for the transcriptional regulation of musashi1 in neural stem/progenitor cells
Kawase S, Imai T, Miyauchi-Hara C, Yaguchi K, Nishimoto Y, Fukami S-i, Matsuzaki Y, Miyawaki A, Itohara S, Okano H
Molecular Brain 13 ( 4 ) 1410 2011.4
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FRS2α regulates Erk levels to control a self-renewal target Hes1 and proliferation of FGF-responsive neural stem/progenitor cells
Sato T, Shimazaki T, Naka H, Fukami S-i, Satoh Y, Okano H, Lax I, Schlessinger J, Gotoh N
Stem Cells 28 ( 9 ) 1661 - 1673 2010.9
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Epidermal growth factor signaling mediated by grb2 associated binder1 is required for the spatiotemporally regulated proliferation of olig2-expressing progenitors in the embryonic spinal cord.
Hayakawa-Yano Y, Nishida K, Fukami S, Gotoh Y, Hirano T, Nakagawa T, Shimazaki T, Okano H
Stem Cells 25 ( 6 ) 1410 - 1422 2007.6
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Transient inhibition of BMP signaling by Noggin induces cardiomyocyte differentiation of mouse embryonic stem cells.
Yuasa S, Itabashi Y, Koshimizu U, Tanaka T, Sugimura K, Kinoshita M, Hattori F, Fukami S-i, Shimazaki T, Okano H, Ogawa S, Fukuda K
Nature Biotechnology 23 ( 5 ) 607 - 611 2005.5
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Mouse suppressor of fused is a negative regulator of sonic hedgehog signaling and alters the subcellular distribution of Gli1.
Ding Q, Fukami S-i, Meng X, Nishizaki Y, Zhang X, Sasaki H, Dlugosz A, Nakafuku M, Hui C
Current Biology 9 ( 19 ) 1119 - 1122 1999.9
Research Projects
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Social experience-dependent myelination in the mPFC and its relevant synapse formation
Grant number：15K15432 2015.4 - 2019.3
Grant-in-Aid for Challenging Exploratory Research
Makinodan Manabu
Grant amount：\3120000 （ Direct Cost: \2400000 、 Indirect Cost：\720000 ）
In this study, we performed in vitro (neuron-oligodendrocyte co-culture)、ex vivo (slice culture)、in vivo (juvenile social isolaion mice and BTBR mice) experiments and aimed to validate the association between myelin formation and its relevant neuronal function and synapse formation. Our study provides no evidnece for the causation, but indicates that there are associations between myelin formation and neuronal function as well as myelin formation and synapse function.