Fukushima Medical University   Endowed Chair Department of Progressive DOHaD Research   Associate Professor

2019.6 - 2020.11

エルゼビアジャパン eReview コミッティメンバー   免疫学

2017.1 - Now

University of Yamanashi   Depertment of Immunology   assistant professor

2016.9 - 2019.5

THE JAPANESE CANCER ASSOCIATION

TGFβ-Responsive Stromal Activation Occurs Early in Serrated Colorectal Carcinogenesis.

Hideaki Tsumuraya, Hirokazu Okayama, Masanori Katagata, Akira Matsuishi, Satoshi Fukai, Misato Ito, Wataru Sakamoto, Motonobu Saito, Tomoyuki Momma, Shotaro Nakajima, Kosaku Mimura, Koji Kono

International journal of molecular sciences   25 ( 9 )   2024.4

Biomarker-oriented chemo-immunotherapy for advanced gastric cancer.

Koji Kono, Shotaro Nakajima, Kosaku Mimura

International journal of clinical oncology   29 ( 7 )   865 - 872   2024.4（ ISSN:1341-9625 ）

Combination of oligo-fractionated irradiation with nivolumab can induce immune modulation in gastric cancer.

Kosaku Mimura, Takashi Ogata, Phuong H D Nguyen, Souvick Roy, Hassen Kared, Yate-Ching Yuan, Michael Fehlings, Yuya Yoshimoto, Daisaku Yoshida, Shotaro Nakajima, Hisashi Sato, Nozomu Machida, Takanobu Yamada, Yohei Watanabe, Tomoaki Tamaki, Hirohito Fujikawa, Yasuhiro Inokuchi, Suguru Hayase, Hiroyuki Hanayama, Zenichiro Saze, Hiroyuki Katoh, Fumiaki Takahashi, Takashi Oshima, Ajay Goel, Alessandra Nardin, Yoshiyuki Suzuki, Koji Kono

Journal for immunotherapy of cancer   12 ( 1 )   2024.1

TIM-3 expression and M2 polarization of macrophages in the TGFβ-activated tumor microenvironment in colorectal cancer

Masanori Katagata, Hirokazu Okayama, Shotaro Nakajima, Katsuharu Saito, Takahiro Sato, Mei Sakuma, Satoshi Fukai, Eisei Endo, Wataru Sakamoto, Motonobu Saito, Zenichiro Saze, Tomoyuki Momma, Kosaku Mimura, Koji Kono

Cancers   20 ( 15 )   4943   2023.10（ ISSN:2072-6694 ）

放射線治療による腫瘍細胞内cGAS-STING経路を介した食道扁平上皮癌微小環境の変化

中嶋正太郎, 三村耕作, 金田晃尚, 片方雅紀, 岡山洋和, 齋藤元伸, 佐瀬善一郎, 花山寛之, 多田武志, 門馬智之, 河野浩二

癌と化学療法   50 ( 10 )   1099 - 1101   2023.10

[Remodeling of the Tumor Microenvironment by Radiotherapy through the cGAS-STING Pathway in Esophageal Squamous Cell Carcinoma].

Nakajima S, Mimura K, Kaneta A, Katagata M, Okayama H, Saito M, Saze Z, Hanayama H, Tada T, Momma T, Kono K

Gan to kagaku ryoho. Cancer & chemotherapy   50 ( 10 )   1099 - 1101   2023.10（ ISSN:0385-0684 ）

Remodeling of the tumor microenvironment by radiotherapy through the cGAS-STING pathway in esophageal squamous cell carcinoma

Shotaro Nakajima, Kosaku Mimura, Akinao Kaneta, Masanori Katagata, Hirokazu Okayama, Motonobu Saito, Zenichiro Saze, Hiroyuki Hanayama, Takeshi Tada, Tomoyuki Momma, Koji Kono

Gan to kagaku ryoho. Cancer & chemotherapy   50 ( 10 )   1099 - 1101   2023.10（ ISSN:0385-0684 ）

[The Potential of a Novel Therapeutic Strategy for Colorectal Cancer Targeting the cGAS-STING Pathway].

Shotaro Nakajima, Akinao Kaneta, Koji Kono

Gan to kagaku ryoho. Cancer & chemotherapy   50 ( 9 )   950 - 954   2023.9（ ISSN:0385-0684 ）

[The Potential of a Novel Therapeutic Strategy for Colorectal Cancer Targeting the cGAS-STING Pathway].

Nakajima S, Kaneta A, Kono K

Gan to kagaku ryoho. Cancer & chemotherapy   50 ( 9 )   950 - 954   2023.9（ ISSN:0385-0684 ）

Phase I/II clinical trial of nivolumab in combination with oligo-fractionated irradiation for unresectable advanced or recurrent gastric cancer.

Kosaku Mimura, Takashi Ogata, Yuya Yoshimoto, Daisaku Yoshida, Shotaro Nakajima, Hisashi Sato, Nozomu Machida, Takanobu Yamada, Yohei Watanabe, Tomoaki Tamaki, Hirohito Fujikawa, Yasuhiro Inokuchi, Suguru Hayase, Hiroyuki Hanayama, Zenichiro Saze, Hiroyuki Katoh, Fumiaki Takahashi, Takashi Oshima, Yoshiyuki Suzuki, Koji Kono

Communications medicine   3 ( 1 )   111 - 111   2023.8

Down-regulation of stimulator of interferon genes (STING) expression and CD8(+) T-cell infiltration depending on HER2 heterogeneity in HER2-positive gastric cancer.

Fukai S, Nakajima S, Saito M, Saito K, Kase K, Nakano H, Sato T, Sakuma M, Kaneta A, Okayama H, Mimura K, Sakamoto W, Saze Z, Momma T, Kono K

Gastric cancer   26 ( 6 )   878 - 890   2023.8

A Potential Biomarker of Dynamic Change in Peripheral CD45RA(-)CD27(+)CD127(+) Central Memory T Cells for Anti-PD-1 Therapy in Patients with Esophageal Squamous Cell Carcinoma.

Sakuma M, Mimura K, Nakajima S, Kaneta A, Kikuchi T, Nirei A, Tada T, Hanayama H, Okayama H, Sakamoto W, Saito M, Momma T, Saze Z, Kono K

Cancers   15 ( 14 )   3641   2023.7（ ISSN:2072-6694 ）

The Impact of Tumor Cell-Intrinsic Expression of Cyclic GMP-AMP Synthase (cGAS)-Stimulator of Interferon Genes (STING) on the Infiltration of CD8(+) T Cells and Clinical Outcomes in Mismatch Repair Proficient/Microsatellite Stable Colorectal Cancer.

Nakajima S, Kaneta A, Okayama H, Saito K, Kikuchi T, Endo E, Matsumoto T, Fukai S, Sakuma M, Sato T, Mimura K, Saito M, Saze Z, Sakamoto W, Onozawa H, Momma T, Kono K

Cancers   15 ( 10 )   2826   2023.5（ ISSN:2072-6694 ）

Radiation-Induced Remodeling of the Tumor Microenvironment Through Tumor Cell-Intrinsic Expression of cGAS-STING in Esophageal Squamous Cell Carcinoma.

Nakajima S, Mimura K, Kaneta A, Saito K, Katagata M, Okayama H, Saito M, Saze Z, Watanabe Y, Hanayama H, Tada T, Sakamoto W, Momma T, Ohira H, Kono K

International journal of radiation oncology, biology, physics   115 ( 4 )   957 - 971   2023.3（ ISSN:0360-3016 ）

M2 tumor-associated macrophages resist to oxidative stress through heme oxygenase-1 in the colorectal cancer tumor microenvironment.

Ito M, Mimura K, Nakajima S, Okayama H, Saito K, Nakajima T, Kikuchi T, Onozawa H, Fujita S, Sakamoto W, Saito M, Momma T, Saze Z, Kono K

Cancer immunology, immunotherapy : CII   72 ( 7 )   2233 - 2244   2023.3（ ISSN:0340-7004 ）

ARID1A deficiency is targetable by AKT inhibitors in HER2-negative gastric cancer.

Sato T, Saito M, Nakajima S, Saito K, Katagata M, Fukai S, Okayama H, Sakamoto W, Saze Z, Momma T, Mimura K, Kono K

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association   26 ( 3 )   379 - 392   2023.2（ ISSN:1436-3291 ）

用語解説

中嶋正太郎

分子細胞免疫学 原著第10版 アバス-リックマン-ピレ   535 - 564   2023.1

Phase I/II clinical trial of nivolumab in combination with oligo-fractionated irradiation for unresectable advanced or recurrent gastric cancer.

Mimura K, Ogata T, Yoshimoto Y, Yoshida D, Nakajima S, Sato H, Machida N, Yamada T, Watanabe Y, Tamaki T, Fujikawa H, Inokuchi Y, Hayase S, Hanayama H, Saze Z, Katoh H, Takahashi F, Oshima T, Suzuki Y, Kono K

Cancer medicine   3 ( 1 )   111   2023

TIM-3 Expression and M2 Polarization of Macrophages in the TGFβ-Activated Tumor Microenvironment in Colorectal Cancer.

Katagata M, Okayama H, Nakajima S, Saito K, Sato T, Sakuma M, Fukai S, Endo E, Sakamoto W, Saito M, Saze Z, Momma T, Mimura K, Kono K

Cancers   15 ( 20 )   4943   2023

cGAS-STING経路を標的とした大腸癌の新規治療戦力の可能性

中嶋正太郎, 金田晃尚, 河野浩二

癌と化学療法   50 ( 9 )   950 - 954   2023

Radiation-induced remodeling of the tumor-microenvironment through tumor cell-intrinsic expression of cGAS-STING in esophageal squamous cell carcinoma.

Shotaro Nakajima, Kosaku Mimura, Akinao Kaneta, Katsuharu Saito, Masanori Katagata, Hirokazu Okayama, Motonobu Saito, Zenichiro Saze, Yohei Watanabe, Hiroyuki Hanayama, Takeshi Tada, Wataru Sakamoto, Tomoyuki Momma, Hiromasa Ohira, Koji Kono

International journal of radiation oncology, biology, physics   115 ( 4 )   957 - 971   2022.11（ ISSN:0360-3016 ）

[Expression of the cGAS-STING Pathway in dMMR/MSI-H in Colorectal Cancer].

Akinao Kaneta, Shotaro Nakajima, Kosaku Mimura, Koji Kono

Gan to kagaku ryoho. Cancer & chemotherapy   49 ( 10 )   1130 - 1132   2022.10（ ISSN:0385-0684 ）

dMMR/MSI-H大腸癌におけるcGAS-STING経路の発現

金田晃尚，中嶋正太郎，三村耕作，河野浩二

癌と化学療法   49 ( 10 )   1130 - 1132   2022.10

Immune escape mechanism behind resistance to anti-PD-1 therapy in gastrointestinal tract metastasis in malignant melanoma patients with multiple metastases

Ito M, Mimura K, Nakajima S, Saito K, Min AKT, Okayama H, Saito M, Momma T, Saze Z, Ohtsuka M, Yamamoto T, Kono K.

Cancer Immunol Immunother.   71 ( 9 )   2293 - 2300   2022.9

Role of the cGAS-STING pathway in regulating the tumor-immune microenvironment in dMMR/MSI colorectal cancer.

Akinao Kaneta, Shotaro Nakajima, Hirokazu Okayama, Takuro Matsumoto, Katsuharu Saito, Tomohiro Kikuchi, Eisei Endo, Misato Ito, Kosaku Mimura, Yasuyuki Kanke, Motonobu Saito, Zenichiro Saze, Shotaro Fujita, Wataru Sakamoto, Hisashi Onozawa, Tomoyuki Momma, Shinji Ohki, Koji Kono

Cancer immunology, immunotherapy : CII   71 ( 11 )   2765 - 2776   2022.4（ ISSN:0340-7004 ）

SH2D4A downregulation due to loss of chromosome 8p is associated with poor prognosis and low T cell infiltration in colorectal cancer.

Matsumoto T, Okayama H, Nakajima S, Saito K, Ito M, Kaneta A, Kanke Y, Onozawa H, Hayase S, Fujita S, Sakamoto W, Saito M, Seze Z, Momma T, Mimura K, Kono K

British journal of cancer   126 ( 6 )   917 - 926   2022.4

SH2D4A downregulation due to loss of chromosome 8p is associated with poor prognosis and low T cell infiltration in colorectal cancer.

Matsumoto T, Okayama H, Nakajima S, Saito K, Ito M, Kaneta A, Kanke Y, Onozawa H, Hayase S, Fujita S, Sakamoto W, Saito M, Seze Z, Momma T, Mimura K, Kono K

British journal of cancer   126 ( 6 )   917 - 926   2022.4（ ISSN:0007-0920 ）

SH2D4A downregulation due to loss of chromosome 8p is associated with poor prognosis and low T cell infiltration in colorectal cancer

Matsumoto T, Okayama H, Nakajima S, Saito K, Ito M, Kaneta A, Kanke Y, Onozawa H, Hayase S, Fujita S, Sakamoto W, Saito M, Seze Z, Momma T, Mimura K, Kono K.

Br J Cancer.   126 ( 6 )   917 - 926   2022.4

Immune escape mechanism behind resistance to anti-PD-1 therapy in gastrointestinal tract metastasis in malignant melanoma patients with multiple metastases

Misato Ito, Kosaku Mimura, Shotaro Nakajima, Katsuharu Saito, Aung Kyi Thar Min, Hirokazu Okayama, Motonobu Saito, Tomoyuki Momma, Zenichiro Saze, Mikio Ohtsuka, Toshiyuki Yamamoto, Koji Kono

Cancer Immunology, Immunotherapy   71 ( 9 )   2293 - 2300   2022.1（ ISSN:0340-7004 ）

SH2D4A downregulation due to loss of chromosome 8p is associated with poor prognosis and low T cell infiltration in colorectal cancer

Matsumoto T, Okayama H, Nakajima S, Saito K, Ito M, Kaneta A, Kanke Y, Onozawa H, Hayase S, Fujita S, Sakamoto W, Saito M, Seze Z, Momma T, Mimura K, Kono K

Br J Cancer   2021.12

ミスマッチ修復機構欠損大腸癌における糖鎖抗原を標的とした免疫療法の可能性

松本拓朗, 岡山洋和, 仲野宏, 伊藤美郷, 中嶋正太郎, 齋藤元伸, 佐瀬善一郎, 門馬智之, 三村耕作, 河野浩二

癌と化学療法   48 ( 10 )   1275 - 1277   2021.10（ ISSN:0385-0684 ）

The Expression of Immune Checkpoint Receptors and Ligands in the Colorectal Cancer Tumor Microenvironment.

Prajwal Neupane, Kosaku Mimura, Shotaro Nakajima, Hirokazu Okayama, Misato Ito, Aung Kyi Thar Min, Katsuharu Saito, Hisashi Onozawa, Shotaro Fujita, Wataru Sakamoto, Motonobu Saito, Zenichiro Saze, Tomoyuki Momma, Koji Kono

Anticancer research   41 ( 10 )   4895 - 4905   2021.10（ ISSN:0250-7005 ）

Immunotherapy Targeting Tumor-Associated Carbohydrate Antigens in Deficient Mismatch Repair Colorectal Cancer

Matsumoto T, Okayama H, Nakano H, Ito M, Nakajima S, Saito M, Saze Z, Momma T, Mimura K, Kono K

Gan to kagaku ryoho. Cancer & chemotherapy   48 ( 10 )   1275 - 1277   2021.10（ ISSN:03850684 ）

The effects of T-DXd on the expression of HLA class I and chemokines CXCL9/10/11 in HER2-overexpressing gastric cancer cells.

Shotaro Nakajima, Kosaku Mimura, Takuro Matsumoto, Aung Kyi Thar Min, Misato Ito, Hiroshi Nakano, Prajwal Neupane, Yasuyuki Kanke, Hirokazu Okayama, Motonobu Saito, Tomoyuki Momma, Yohei Watanabe, Hiroyuki Hanayama, Suguru Hayase, Zenichiro Saze, Koji Kono

Scientific reports   11 ( 1 )   16891 - 16891   2021.8

Chemoradiation induces upregulation of immunogenic cell death-related molecules together with increased expression of PD-L1 and galectin-9 in gastric cancer.

S H Petersen, L F Kua, S Nakajima, W P Yong, K Kono

Scientific reports   11 ( 1 )   12264 - 12264   2021.6

Stromal expression of cancer-associated fibroblast-related molecules, versican and lumican, is strongly associated with worse relapse-free and overall survival times in patients with esophageal squamous cell carcinoma.

Naoto Yamauchi, Yasuyuki Kanke, Katsuharu Saito, Hirokazu Okayama, Shoki Yamada, Shotaro Nakajima, Eisei Endo, Koji Kase, Leo Yamada, Hiroshi Nakano, Takuro Matsumoto, Hiroyuki Hanayama, Yohei Watanabe, Suguru Hayase, Motonobu Saito, Zenichiro Saze, Kosaku Mimura, Tomoyuki Momma, Shinji Oki, Yuko Hashimoto, Koji Kono

Oncology letters   21 ( 6 )   445 - 445   2021.6（ ISSN:1792-1074 ）

Neoadjuvant chemotherapy induces IL-34 signaling and promotes chemoresistance via tumor-associated macrophage polarization in esophageal squamous cell carcinoma.

Shotaro Nakajima, Kosaku Mimura, Katsuharu Saito, Aung Kyi Thar Min, Eisei Endo, Leo Yamada, Koji Kase, Naoto Yamauchi, Takuro Matsumoto, Hiroshi Nakano, Yasuyuki Kanke, Hirokazu Okayama, Motonobu Saito, Prajwal Neupane, Zenichiro Saze, Yohei Watanabe, Hiroyuki Hanayama, Suguru Hayase, Akinao Kaneta, Tomoyuki Momma, Shinji Ohki, Hiromasa Ohira, Koji Kono

Molecular cancer research : MCR   19 ( 6 )   1085 - 1095   2021.6（ ISSN:1541-7786 ）

ARID1A deficiency in EBV-positive gastric cancer is partially regulated by EBV-encoded miRNAs, but not by DNA promotor hypermethylation.

Koji Kase, Motonobu Saito, Shotaro Nakajima, Daisuke Takayanagi, Katsuharu Saito, Leo Yamada, Mai Ashizawa, Hiroshi Nakano, Hiroyuki Hanayama, Hisashi Onozawa, Hirokazu Okayama, Hisahito Endo, Shotaro Fujita, Wataru Sakamoto, Zenichiro Saze, Tomoyuki Momma, Kosaku Mimura, Shinji Ohki, Kouya Shiraishi, Takashi Kohno, Koji Kono

Carcinogenesis   42 ( 1 )   21 - 30   2021.2（ ISSN:0143-3334 ）

Therapeutic potential of anti-VEGF receptor 2 therapy targeting for M2-tumor-associated macrophages in colorectal cancer.

Aung Kyi Thar Min, Kosaku Mimura, Shotaro Nakajima, Hirokazu Okayama, Katsuharu Saito, Wataru Sakamoto, Shotaro Fujita, Hisahito Endo, Motonobu Saito, Zenichiro Saze, Tomoyuki Momma, Shinji Ohki, Koji Kono

Cancer immunology, immunotherapy : CII   70 ( 2 )   289 - 298   2021.2（ ISSN:0340-7004 ）

PD-L1 overexpression in EBV-positive gastric cancer is caused by unique genomic or epigenomic mechanisms.

Hiroshi Nakano, Motonobu Saito, Shotaro Nakajima, Katsuharu Saito, Yuko Nakayama, Koji Kase, Leo Yamada, Yasuyuki Kanke, Hiroyuki Hanayama, Hisashi Onozawa, Hirokazu Okayama, Shotaro Fujita, Wataru Sakamoto, Zenichiro Saze, Tomoyuki Momma, Kosaku Mimura, Shinji Ohki, Akiteru Goto, Koji Kono

Scientific reports   11 ( 1 )   1982 - 1982   2021.1

Selective sensitivity of EZH2 inhibitors based on synthetic lethality in ARID1A-deficient gastric cancer.

Leo Yamada, Motonobu Saito, Aung Kyi Thar Min, Katsuharu Saito, Mai Ashizawa, Koji Kase, Shotaro Nakajima, Hisashi Onozawa, Hirokazu Okayama, Hisahito Endo, Shotaro Fujita, Wataru Sakamoto, Zenichiro Saze, Tomoyuki Momma, Kosaku Mimura, Shinji Ohki, Koji Kono

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association   24 ( 1 )   60 - 71   2021.1（ ISSN:1436-3291 ）

Selective sensitivity of EZH2 inhibitors based on synthetic lethality in ARID1A-deficient gastric cancer.

Yamada L, Saito M, Thar Min AK, Saito K, Ashizawa M, Kase K, Nakajima S, Onozawa H, Okayama H, Endo H, Fujita S, Sakamoto W, Saze Z, Momma T, Mimura K, Ohki S, Kono K

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association   24 ( 1 )   60 - 71   2021.1（ ISSN:1436-3291 ）

Activation of the reward system ameliorates passive cutaneous anaphylactic reaction in mice.

Shotaro Nakajima, Satoshi Manita, Guannan Yu, Kayoko Ishimaru, Koji Kono, Kazuo Kitamura, Atsuhito Nakao

Allergy   75 ( 12 )   3275 - 3279   2020.12（ ISSN:0105-4538 ）

Tn Antigen Expression Defines an Immune Cold Subset of Mismatch-Repair Deficient Colorectal Cancer.

Takuro Matsumoto, Hirokazu Okayama, Shotaro Nakajima, Katsuharu Saito, Hiroshi Nakano, Eisei Endo, Koji Kase, Misato Ito, Naoto Yamauchi, Leo Yamada, Yasuyuki Kanke, Hisashi Onozawa, Shotaro Fujita, Wataru Sakamoto, Motonobu Saito, Zenichiro Saze, Tomoyuki Momma, Kosaku Mimura, Koji Kono

International journal of molecular sciences   21 ( 23 )   9081 - 9081   2020.11（ ISSN:16616596 ）

A TGFβ-dependent stromal subset underlies immune checkpoint inhibitor efficacy in DNA mismatch repair-deficient/microsatellite instability-high colorectal cancer.

Eisei Endo, Hirokazu Okayama, Katsuharu Saito, Shotaro Nakajima, Leo Yamada, Daisuke Ujiie, Koji Kase, Shotaro Fujita, Hisahito Endo, Wataru Sakamoto, Motonobu Saito, Zenichiro Saze, Tomoyuki Momma, Shinji Ohki, Kosaku Mimura, Koji Kono

Molecular cancer research : MCR   18 ( 9 )   1402 - 1413   2020.9（ ISSN:1541-7786 ）

Current status of immune checkpoint inhibitors for gastric cancer.

Koji Kono, Shotaro Nakajima, Kosaku Mimura

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association   23 ( 4 )   565 - 578   2020.7（ ISSN:1436-3291 ）

Current status of immune checkpoint inhibitors for gastric cancer.

Kono K, Nakajima S, Mimura K.

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association   23 ( 4 )   565 - 578   2020.7（ ISSN:1436-3291 ）

cutting-edge medicineがん診療の副作用マネジメント　複合がん免疫療法の発展を目指して

中嶋 正太郎, 河野 浩二

Precision Medicine   3 ( 4 )   299 - 302   2020.4（ ISSN:2434-3625 ）

cutting-edge medicine –The development of combination cancer immunotherapy–

Shotaro Nakajima, Koji Kono

Precision Medicine   ( 4 )   1 - 4   2020.3

Changes in the mental health status of adolescents following the Fukushima Daiichi nuclear accident and related factors: Fukushima Health Management Survey.

Hayashi F, Sanpei M, Ohira T, Nakano H, Okazaki K, Yasumura S, Nakajima S, Yabe H, Suzuki Y, Kamiya K, Fukushima Health Management Survey Group

Journal of affective disorders   260   432 - 439   2020.1（ ISSN:0165-0327 ）

第10 章 腫瘍免疫学と移植免疫学 がん細胞と正常非自己細胞に対する免疫応答

中尾篤人，井上修，氏家大輔，内田萌菜，柏木麻里子，香山尚子，河合利尚，木村元子，河野浩二，佐藤卓哉，竹田潔，中嶋正太郎，中野信浩，中山俊憲，中山勝文，廣瀬晃一，穂積勝人，村上正晃，村上悠二，八木良二，松嶋綱治，山田幸宏

基礎免疫学 原著第6 版 免疫系の機能とその異常   185 - 205   2020

The Putatively Specific Synthetic REV-ERB Agonist SR9009 Inhibits IgE- and IL-33-Mediated Mast Cell Activation Independently of the Circadian Clock.

Ishimaru K, Nakajima S, Yu G, Nakamura Y, Nakao A

International journal of molecular sciences   20 ( 24 )   2019.12（ ISSN:16616596 ）

Resveratrol inhibits IL-33-mediated mast cell activation by targeting the MK2/3-PI3K/Akt axis.

Nakajima S, Ishimaru K, Kobayashi A, Yu G, Nakamura Y, Oh-Oka K, Suzuki-Inoue K, Kono K, Nakao A

Scientific reports   9 ( 1 )   18423   2019.12

The frequency of Th17 cells in the small intestine exhibits a day-night variation dependent on circadian clock activity.

Ha Pham Thu Le, Yuki Nakamura, Kyoko Oh-Oka, Kayoko Ishimaru, Shotaro Nakajima, Atsuhito Nakao

Biochemical and biophysical research communications   490 ( 2 )   290 - 295   2017.8

Induction of Colonic Regulatory T Cells by Mesalamine by Activating the Aryl Hydrocarbon Receptor.

Kyoko Oh-Oka, Yuko Kojima, Koichiro Uchida, Kimiko Yoda, Kayoko Ishimaru, Shotaro Nakajima, Jun Hemmi, Hiroshi Kano, Yoshiaki Fujii-Kuriyama, Ryohei Katoh, Hiroyuki Ito, Atsuhito Nakao

Cellular and molecular gastroenterology and hepatology   4 ( 1 )   135 - 151   2017.7

Upregulation of thioredoxin-1 in activated human NK cells confers increased tolerance to oxidative stress.

Mimura K, Kua LF, Shimasaki N, Shiraishi K, Nakajima S, Siang LK, Shabbir A, So J, Yong WP, Kono K

Cancer immunology, immunotherapy : CII   66 ( 5 )   605 - 613   2017.5（ ISSN:0340-7004 ）

Selective deletion of adipocytes, but not preadipocytes, by TNF-α through C/EBP- and PPARγ-mediated suppression of NF-κB.

Minori Tamai, Tsuyoshi Shimada, Nobuhiko Hiramatsu, Kunihiro Hayakawa, Maro Okamura, Yasuhiro Tagawa, Shuhei Takahashi, Shotaro Nakajima, Jian Yao, Masanori Kitamura

Laboratory investigation; a journal of technical methods and pathology   97 ( 2 )   228 - 228   2017.2

Inhibition of MMP activity can restore NKG2D ligand expression in gastric cancer, leading to improved NK cell susceptibility.

Shiraishi K, Mimura K, Kua LF, Koh V, Siang LK, Nakajima S, Fujii H, Shabbir A, Yong WP, So J, Takenoshita S, Kono K

Journal of gastroenterology   51 ( 12 )   1101 - 1111   2016.12（ ISSN:0944-1174 ）

Accumulation of CD11c+CD163+ Adipose Tissue Macrophages through Upregulation of Intracellular 11β-HSD1 in Human Obesity.

Nakajima S, Koh V, Kua LF, So J, Davide L, Lim KS, Petersen SH, Yong WP, Shabbir A, Kono K

Journal of immunology (Baltimore, Md. : 1950)   197 ( 9 )   3735 - 3745   2016.11（ ISSN:0022-1767 ）

eIF2α-independent inhibition of TNF-α-Triggered NF-κB activation by salubrinal

Nakajima S., Chi Y., Gao K., Kono K., Yao J.

Biological and Pharmaceutical Bulletin   38 ( 9 )   1368 - 1374   2015.9（ ISSN:09186158 ）

Purinergic control of AMPK activation by ATP released through connexin 43 hemichannels - pivotal roles in hemichannel-mediated cell injury.

Yuan Chi, Kun Gao, Kai Li, Shotaro Nakajima, Satoru Kira, Masayuki Takeda, Jian Yao

Journal of cell science   127 ( Pt 7 )   1487 - 99   2014.4

Acidic stress-ER stress axis for blunted activation of NF-kappa B in mesothelial cells exposed to peritoneal dialysis fluid (vol 27, pg 4053, 2012)

Hisashi Johno, Ryouji Ogata, Shotaro Nakajima, Nobuhiko Hiramatsu, Tetsuro Kobayashi, Hideaki Hara, Masanori Kitamura

NEPHROLOGY DIALYSIS TRANSPLANTATION   29 ( 2 )   470 - 470   2014.2（ ISSN:0931-0509 ）

Bidirectional regulation of NF-κB by reactive oxygen species: a role of unfolded protein response.

Shotaro Nakajima, Masanori Kitamura

Free radical biology & medicine   65   162 - 174   2013.12（ ISSN:0891-5849 ）

Selective, potent blockade of the IRE1 and ATF6 pathways by 4-phenylbutyric acid analogues.

Hui Zhang, Shotaro Nakajima, Hironori Kato, Liubao Gu, Tatsuya Yoshitomi, Kaoru Nagai, Hideyuki Shinmori, Susumu Kokubo, Masanori Kitamura

British journal of pharmacology   170 ( 4 )   822 - 34   2013.10

Intervention in genotoxic stress-induced senescence by cordycepin through activation of eIF2α and suppression of Sp1.

Liubao Gu, Hisashi Johno, Shotaro Nakajima, Tatsuya Yoshitomi, Shuhei Takahashi, Masanori Kitamura

Toxicological sciences : an official journal of the Society of Toxicology   134 ( 2 )   345 - 54   2013.8

Pleiotropic Potential of Dehydroxymethylepoxyquinomicin for NF-kappa B Suppression via Reactive Oxygen Species and Unfolded Protein Response

Shotaro Nakajima, Hironori Kato, Liubao Gu, Shuhei Takahashi, Hisashi Johno, Kazuo Umezawa, Masanori Kitamura

JOURNAL OF IMMUNOLOGY   190 ( 12 )   6559 - 6569   2013.6（ ISSN:0022-1767 ）

Blockade of Smad signaling by 3'-deoxyadenosine: a mechanism for its anti-fibrotic potential.

Liubao Gu, Hisashi Johno, Shotaro Nakajima, Hironori Kato, Shuhei Takahashi, Ryohei Katoh, Masanori Kitamura

Laboratory investigation; a journal of technical methods and pathology   93 ( 4 )   450 - 61   2013.4

Phase I/II clinical trial of nivolumab in combination with oligo-fractionated irradiation for patients with advanced gastric cancer

The 3rd International Congress of the Asian Oncology Society   2023.10  

Frequency of exhausted T cells after chemotherapy or chemoradiotherapy in patients with esophageal squamous cell carcinoma

The 3rd International Congress of the Asian Oncology Society   2023.10  

Involvement of several inhibitory immune checkpoint ligands in anti-PD-1 antibody therapy-resistant cases with malignant melanoma

The 3rd International Congress of the Asian Oncology Society   2023.10  

The effect of IL-34 triggered by neoadjuvant chemotherapy on the tumor-microenvironment and clinical outcomes in patients with esophageal squamous cell carcinoma

The 3rd International Congress of the Asian Oncology Society   2023.10  

Short-term outcomes of esophagectomy for elderly patients

The 3rd International Congress of the Asian Oncology Society   2023.10  

TGFβ活性を有する腫瘍微小環境のTIM-3とM2マクロファージへの影響について

第61回日本癌治療学会学術集会   2023.10  

大腸癌腫瘍微小環境における免疫チェックポイントリガンドの発現

第61回日本癌治療学会学術集会   2023.10  

大腸癌TMEにおけるHO-1発現を介するM2腫瘍関連マクロファージの浸潤頻度増加について

第61回日本癌治療学会学術集会   2023.10  

TGF β-activated tumor microenvironment in serrated colorectal neoplasia

第61回日本癌治療学会学術集会   2023.10  

腫瘍細胞内cGAS-STING経路がpMMR/MSS大腸癌のCD8+T細胞浸潤や予後に及ぼす影響

第82回日本癌学会学術総会   2023.9  

The impact of CLDN18 expression and natural killer cell infiltration on clinical outcomes in patients with gastric cancer

SGCC 14th Annual Scientific Meeting and JSPS-NUS Research Seminar   2023.7  

Frequency of exhausted T cells after chemotherapy or chemoradiotherapy in patients with esophageal squamous cell carcinoma

SGCC 14th Annual Scientific Meeting and JSPS-NUS Research Seminar   2023.7  

The Effect of Chemotherapy-Induced IL-34 Expression on the Tumor Immune Microenvironment in Esophageal Cancer.

SGCC 14th Annual Scientific Meeting and JSPS-NUS Research Seminar   2023.7  

Potential of liquid biopsy using flow cytometry and repertoire analysis for advanced gastric cancer

2023.7  

進行・再発食道扁平上皮癌症例におけるnivolumab奏功群の免疫学的特徴

第78回日本消化器外科学会総会   2023.7  

癌間質におけるTGF-βと腫瘍浸潤免疫細胞でのTIM3の発現との関連について

第78回日本消化器外科学会総会   2023.7  

HER2陽性胃がんにおいてHER2経路がSTINGやCD8＋T細胞に及ぼす影響

第44回癌免疫外科研究会   2023.6  

放射線治療による腫瘍細胞内cGAS-STING経路を介した食道扁平上皮癌微小環境の変化

第44回癌免疫外科研究会   2023.6  

抗 PD-1 療法不応性病変のメカニズムと治療戦略について

第123回日本外科学会定期学術集会   2023.4  

HER2 陽性胃癌における cGAS-STING 経路の役割

第123回日本外科学会定期学術集会   2023.4  

癌間質における TGF-βと腫瘍浸潤免疫細胞での TIM3 の発現との関連について

第123回日本外科学会定期学術集会   2023.4  

Molecular subtypes of colorectal cancer

第123回日本外科学会定期学術集会   2023.4  

Neoadjuvant che-motherapy- induced IL34 signaling promotes chemoresistance in esophageal cancer

Fukushima-NIH National Cancer Institute Joint Symposium   2023.1  

大腸癌における腫瘍細胞内 cGAS-STING経路を標的とした新規治療戦略

第35回日本バイオセラピィ学会学術集会総会   2022.12  

放射線治療による腫瘍細胞内 cGAS-STING経路を介した食道扁平上皮癌微小環境リモデリング機構の解明

第35回日本バイオセラピィ学会学術集会総会   2022.12  

上部消化管癌における抗PD-1療法と局所放射線療法を用いた複合がん免疫療法の開発

第35回日本バイオセラピィ学会学術集会総会   2022.12  

癌間質におけるTGF-βと腫瘍浸潤免疫細胞でのTIM3の発現との関連について

第35回日本バイオセラピィ学会学術集会総会   2022.12  

ARID1A欠損胃癌に対するAKT阻害薬の有効性

第35回日本バイオセラピィ学会学術集会総会   2022.12  

HER2陽性胃癌におけるcGAS-STING経路の役割

第35回日本バイオセラピィ学会学術集会総会   2022.12  

Targeting the tumor immune microenvironment in colorectal cancer

2022.12  

大腸癌腫瘍微小環境におけるM2腫瘍関連マクロファージの浸潤頻度増加機序について

第60回日本癌治療学会学術集会   2022.10  

大腸癌における免疫チェックポイントリガンドの発現状況について

第60回日本癌治療学会学術集会   2022.10  

dMMR/MSI大腸癌におけるSTING高発現はCD8陽性T細胞の高浸潤に寄与する

第60回日本癌治療学会学術集会   2022.10  

大腸癌の腫瘍免疫抑制機構

第60回日本癌治療学会学術集会   2022.10  

大腸癌腫瘍微小環境における M2 腫瘍関連マクロファージの浸潤機序について

第77回日本消化器外科学会総会   2022.7  

進行食道扁平上皮癌症例における複合がん免疫療法の開発

第77回日本消化器外科学会総会   2022.7  

進⾏⾷道扁平上⽪癌における抗 PD-1 療法と局所放射線療法を⽤いた複合がん 免疫療法の開発

第43回癌免疫外科研究会   2022.5  

dMMR/MSI ⼤腸癌における cGAS-STING 経路の発現

第43回癌免疫外科研究会   2022.5  

術前補助化学療法が⾷道扁平上⽪癌腫瘍微⼩環境に及ぼす影響

第43回癌免疫外科研究会   2022.5  

大腸癌腫瘍微小環境における免疫チェックポイントレセプターとリガンドの発現について

第122回日本外科学会定期学術集会   2022.4  

術前化学療法が食道扁平上皮癌の腫瘍随伴マクロファージおよび腫瘍微小環境に及ぼす影響

第122回日本外科学会定期学術集会   2022.4  

抗VEGFR2抗体を用いたM2腫瘍関連マクロファージ制御の可能性について

第122回日本外科学会定期学術集会   2022.4  

EBV関連胃癌におけるPD-L1高発現は2つの異なる機序により引き起こされる

第122回日本外科学会定期学術集会   2022.4  

食道扁平上皮癌における間質のCAFs関連分子発現は予後に関連する

第122回日本外科学会定期学術集会   2022.4  

当科における働き方改革への対応と医学博士・内視鏡外科技術認定医「量産」への取り組み

第122回日本外科学会定期学術集会   2022.4  

胃癌サブタイプにおける PD-L1 発現の比較検討

第122回日本外科学会定期学術集会   2022.4  

CD163 陽性 M2 腫瘍関連マクロファージと PD-1 を標的とした複合がん免疫療法の開発

第122回日本外科学会定期学術集会   2022.4  

術前補助化学療法が食道扁平上皮癌微小環境に及ぼす影響

第34回日本バイオセラピィ学会学術集会総会  

食道扁平上皮癌の術前化学療法が誘導するIL-34がマクロファージのM2分極と薬剤感受性低下を促進する

第80回日本癌学会学術総会  

術前補助化学療法により産生されるIL-34が食道扁平上皮癌の腫瘍随伴マクロファージ及び薬剤感受性に及ぼす影響

第42回癌免疫外科研究会  

術前化学療法が食道癌微小環境に及ぼす影響の解析

第33回日本バイオセラピィ学会学術集会総会  

EBV関連胃癌におけるPD-L1発現機序の解明とCD47の発現検討

第33回日本バイオセラピィ学会学術集会総会  

dMMR大腸癌におけるTn抗原の発現

第33回日本バイオセラピィ学会学術集会総会  

胃癌の抗PD-1抗体療法におけるphospho-STAT1のバイオマーカーとしての可能性について

第58回日本癌治療学会学術集会  

結腸直腸癌の腫瘍微小環境におけるTreg および腫瘍関連マクロファージの有病率

第58回日本癌治療学会学術集会  

胃癌におけるPD-L2発現のメカニズム

第58回日本癌治療学会学術集会   2020.10  

胃癌患者におけるPD-L1とPD-L2発現

第58回日本癌治療学会学術集会   2020.10  

食道扁平上皮癌における上皮間葉転換を起こした腫瘍細胞に対する抗PD-1療法について

第58回日本癌治療学会学術集会   2020.10  

抗PD-1抗体による pMMR/MSI-L/MSS大腸癌の治療の可能性について

第58回日本癌治療学会学術集会   2020.10  

EBV関連胃癌におけるエピジェネティック修飾によるARID1A発現制御の検討

第58回日本癌治療学会学術集会   2020.10  

食道扁平上皮癌症例におけるCAFs関連分子発現の予後バイオマーカーとしての検討

第58回日本癌治療学会学術集会   2020.10  

染色体不安定性による癌抑制遺伝子の欠失と腫瘍免疫抑制機構

第58回日本癌治療学会学術集会   2020.10  

食道扁平上皮癌における術前補助化学療法が腫瘍随伴マクロファージに及ぼす影響

第79回日本癌学会学術総会  

放射線照射が誘導する食道癌微小環境でのM2マクロファージの変化-複合がん免疫療法の発展を目指して-

第32回日本バイオセラピィ学会学術集会総会  

低線量被曝が腫瘍随伴マクロファージの分化・機能に及ぼす影響

2022.4 - 2023.3

神沼 修、中嶋 正太郎

抗癌剤による食道扁平上皮癌微小環境におけるIL-34調節機構とTAMとの関連

Grant number：21K08758  2021.4 - 2024.3

基盤研究(C)

門馬 智之, 河野 浩二, 中嶋 正太郎

低線量被曝が腫瘍随伴マクロファージの分化・機能に及ぼす影響

2021.4 - 2022.3

神沼 修、中嶋 正太郎

抗癌剤による食道扁平上皮癌微小環境におけるIL-34調節機構とTAMとの関連

2021.3 - 2024.3

門馬 智之、中嶋 正太郎

The development of radio-immunotherapy for ESCC focusing on tumor-associated macrophages

Grant number：20K17695  2020.4 - 2022.3

Grant-in-Aid for Early-Career Scientists

Shotaro Nakajima

Effects of adipose tissue macrophages on mast cell metabolism

Grant number：18K16142  2018.4 - 2020.3

Grant-in-Aid for Early-Career Scientists

Nakajima Shotaro

「病は気から」は本当か？アレルギー界の大きな謎に挑む！

2017.6

中嶋正太郎