【Constructive Understanding of Multi-scale Dynamism of Neuropsychiatric Disorders】Dysregulation of DPYSL2 expression by mTOR signaling in schizophrenia: Multi-level study of postmortem brain(和訳中)

Izumi Ryuta, Hino Mizuki, Nagaoka Atsuko, Shishido Risa, Kakita Akiyoshi, Hoshino Mikio, Kunii Yasuto, Yabe Hirooki

Neuroscience Research   175   73 - 81   2022.2（ ISSN:0168-0102 ）

High-sucrose diets contribute to brain angiopathy with impaired glucose uptake and psychosis-related higher brain dysfunctions in mice.

Hirai S, Miwa H, Tanaka T, Toriumi K, Kunii Y, Shimbo H, Sakamoto T, Hino M, Izumi R, Nagaoka A, Yabe H, Nakamachi T, Shioda S, Dan T, Miyata T, Nishito Y, Suzuki K, Miyashita M, Tomoda T, Hikida T, Horiuchi J, Itokawa M, Arai M, Okado H

Science advances   7 ( 46 )   eabl6077   2021.11

Evidence for Altered Phosphoinositide Signaling-Associated Molecules in the Postmortem Prefrontal Cortex of Patients with Schizophrenia.

Kunii Y, Matsumoto J, Izumi R, Nagaoka A, Hino M, Shishido R, Sainouchi M, Akatsu H, Hashizume Y, Kakita A, Yabe H

International journal of molecular sciences   22 ( 15 )   2021.7

Detailed Postmortem Profiling of Inflammatory Mediators Expression Revealed Post-inflammatory Alternation in the Superior Temporal Gyrus of Schizophrenia.

Izumi R, Hino M, Wada A, Nagaoka A, Kawamura T, Mori T, Sainouchi M, Kakita A, Kasai K, Kunii Y, Yabe H

Frontiers in psychiatry   12   653821   2021（ ISSN:1664-0640 ）

Ethnicity-Dependent Effects of Schizophrenia Risk Variants of the OLIG2 Gene on OLIG2 Transcription and White Matter Integrity.

Komatsu H, Takeuchi H, Kikuchi Y, Ono C, Yu Z, Iizuka K, Takano Y, Kakuto Y, Funakoshi S, Ono T, Ito J, Kunii Y, Hino M, Nagaoka A, Iwasaki Y, Yamamori H, Yasuda Y, Fujimoto M, Azechi H, Kudo N, Hashimoto R, Yabe H, Yoshida M, Saito Y, Kakita A, Fuse N, Kawashima R, Taki Y, Tomita H

Schizophrenia bulletin   46 ( 6 )   1619 - 1628   2020.4（ ISSN:0586-7614 ）

ALDH4A1 expression levels are elevated in postmortem brains of patients with schizophrenia and are associated with genetic variants in enzymes related to proline metabolism.

Nagaoka A, Kunii Y, Hino M, Izumi R, Nagashima C, Takeshima A, Sainouchi M, Nawa H, Kakita A, Yabe H

Journal of psychiatric research   123   119 - 127   2020.4（ ISSN:0022-3956 ）

Differential protein expression of DARPP-32 versus Calcineurin in the prefrontal cortex and nucleus accumbens in schizophrenia and bipolar disorder.

Kunii Y, Hino M, Matsumoto J, Nagaoka A, Nawa H, Kakita A, Akatsu H, Hashizume Y, Yabe H

Scientific reports   9 ( 1 )   14877   2019.10

Minimal amount of tissue-based pH measurement to improve quality control in neuropsychiatric post-mortem brain studies(和訳中)

Ono Chiaki T., Yu Zhiqian, Kikuchi Yoshie, Kunii Yasuto, Hino Mizuki, Matsumoto Junya, Nagaoka Atsuko, Ito Junko, Iwasaki Yasushi, Hagihara Hideo, Miyakawa Tsuyoshi, Yoshida Mari, Saito Yuko, Niwa Shin-ichi, Yabe Hirooki, Kakita Akiyoshi, Tomita Hiroaki

Psychiatry and Clinical Neurosciences   73 ( 9-10 )   566 - 573   2019.10（ ISSN:1323-1316 ）

Investigation of betaine as a novel psychotherapeutic for schizophrenia.

Ohnishi T, Balan S, Toyoshima M, Maekawa M, Ohba H, Watanabe A, Iwayama Y, Fujita Y, Tan Y, Hisano Y, Shimamoto-Mitsuyama C, Nozaki Y, Esaki K, Nagaoka A, Matsumoto J, Hino M, Mataga N, Hayashi-Takagi A, Hashimoto K, Kunii Y, Kakita A, Yabe H, Yoshikawa T

EBioMedicine   45   432 - 446   2019.7

統合失調症患者における脳内コンドロイチン硫酸鎖の変化

湯川 尊行, 岩倉 百合子, 武井 延之, 斎藤 摩美, 渡部 雄一郎, 豊岡 和彦, 五十嵐 道弘, 新里 和弘, 大島 健一, 國井 泰人, 矢部 博興, 松本 純弥, 和田 明, 日野 瑞城, 入谷 修司, 丹羽 真一, 竹内 亮子, 高橋 均, 柿田 明美, 染矢 俊幸, 那波 宏之

精神神経学雑誌   ( 2019特別号 )   S410 - S410   2019.6（ ISSN:0033-2658 ）

統合失調症患者の脳内ゲノムにおけるコピー数変異の評価

坂井 美和子, 渡部 雄一郎, 染矢 俊幸, 荒木 一明, 澁谷 雅子, 新里 和弘, 大島 健一, 國井 泰人, 矢部 博興, 松本 純弥, 和田 明, 日野 瑞城, 橋本 健志, 菱本 明豊, 北村 登, 入谷 修司, 白川 治, 前田 潔, 宮下 哲典, 丹羽 真一, 高橋 均, 柿田 明美, 桑野 良三, 那波 宏之

精神神経学雑誌   ( 2019特別号 )   S603 - S603   2019.6（ ISSN:0033-2658 ）

A minimal amount of tissue-based pH measurement to improve quality control in neuropsychiatric postmortem brain studies.

Ono CT, Yu Z, Kikuchi Y, Kunii Y, Hino M, Matsumoto J, Nagaoka A, Ito J, Iwasaki Y, Hagihara H, Miyakawa T, Yoshida M, Saito Y, Niwa SI, Yabe H, Kakita A, Tomita H

Psychiatry and clinical neurosciences   73 ( 9 )   566 - 573   2019.5（ ISSN:1323-1316 ）

Pathological alterations of chondroitin sulfate moiety in postmortem hippocampus of patients with schizophrenia.

Yukawa T, Iwakura Y, Takei N, Saito M, Watanabe Y, Toyooka K, Igarashi M, Niizato K, Oshima K, Kunii Y, Yabe H, Matsumoto J, Wada A, Hino M, Iritani S, Niwa SI, Takeuchi R, Takahashi H, Kakita A, Someya T, Nawa H

Psychiatry research   270   940 - 946   2018.12（ ISSN:0165-1781 ）

脳からみた精神科臨床-精神科ブレインバンクへの期待- 精神科臨床と死後脳とを結ぶ研究とは

國井 泰人, 長岡 敦子, 日野 瑞城, 松本 純弥, 丹羽 真一, 矢部 博興

精神神経学雑誌   ( 2018特別号 )   S326 - S326   2018.6（ ISSN:0033-2658 ）

DNA methylation of ANKK1 and response to aripiprazole in patients with acute schizophrenia: A preliminary study.

Miura I, Kunii Y, Hino M, Hoshino H, Matsumoto J, Kanno-Nozaki K, Horikoshi S, Kaneko H, Bundo M, Iwamoto K, Yabe H

Journal of psychiatric research   100   84 - 87   2018.5（ ISSN:0022-3956 ）

Influences of the T102C polymorphism in the 5-HT2A receptor gene on the five-factor model of Positive and Negative Syndrome Scale and treatment response to aripiprazole in patients with acute schizophrenia.

Kanno-Nozaki K, Miura I, Kaneko H, Horikoshi S, Ota T, Nozaki M, Ejiri H, Yahiro M, Watanabe K, Hino M, Yabe H

Psychiatry research   265   244 - 245   2018.5（ ISSN:0165-1781 ）

【精神科臨床と脳病理-精神科ブレインバンクへの期待】 生前登録制度に基づく精神疾患ブレインバンクの実践　当事者と研究者が協働する研究体制とは

國井 泰人, 松本 純弥, 長岡 敦子, 日野 瑞城, 丹羽 真一, 矢部 博興

精神神経学雑誌   120 ( 4 )   269 - 276   2018.4（ ISSN:0033-2658 ）

Effects of the -141C insertion/deletion polymorphism in the dopamine D2 receptor gene on the dopamine system in the striatum in patients with schizophrenia.

Matsumoto J, Nagaoka A, Kunii Y, Miura I, Hino M, Niwa SI, Nawa H, Takahashi H, Kakita A, Yabe H

Psychiatry research   264   116 - 118   2018.3（ ISSN:0165-1781 ）

<i>COMT</i> Val 108/158 Met polymorphism and treatment response to aripiprazole in patients with acute schizophrenia.

Kaneko H, Miura I, Kanno-Nozaki K, Horikoshi S, Hino M, Yabe H

Neuropsychiatric disease and treatment   14   1657 - 1663   2018（ ISSN:1176-6328 ）

Our Practice in Organizing Psychiatric Brain Bank : With Particular Emphasis on "Pre-Registered Donation System"

120 ( 4 )   269 - 276   2018（ ISSN:0033-2658 ）

A Consideration of Molecular Basis of the Auditory Hallucination : Through a Case of the Patient with Colon Cancer Who Showed Transient Verval Hallucination Just After the Administration of Anti-EGFR Antibody or Anti-VEGF Antibody

59 ( 12 )   1141 - 1145   2017.12（ ISSN:0488-1281 ）

幻聴体験の分子メカニズムを考える　抗EGFR抗体,抗VEGF抗体の投与後に一過性の対話性幻聴を呈した1例

長岡 敦子, 國井 泰人, 松本 純弥, 日野 瑞城, 矢部 博興

精神医学   59 ( 12 )   1141 - 1145   2017.12（ ISSN:0488-1281 ）

PKA activation and endothelial claudin-5 breakdown in the schizophrenic prefrontal cortex.

Nishiura K, Ichikawa-Tomikawa N, Sugimoto K, Kunii Y, Kashiwagi K, Tanaka M, Yokoyama Y, Hino M, Sugino T, Yabe H, Takahashi H, Kakita A, Imura T, Chiba H

Oncotarget   8 ( 55 )   93382 - 93391   2017.11

分子標的剤副作用例と死後脳研究に基づく、統合失調症における幻聴体験の分子メカニズムの考察

長岡 敦子, 國井 泰人, 松本 純弥, 日野 瑞城, 矢部 博興, 宮川 哲平, 飯田 聡, 山崎 繁

福島医学雑誌   67 ( 2 )   101 - 102   2017.8（ ISSN:0016-2582 ）

High-Speed and Scalable Whole-Brain Imaging in Rodents and Primates.

Seiriki K, Kasai A, Hashimoto T, Schulze W, Niu M, Yamaguchi S, Nakazawa T, Inoue KI, Uezono S, Takada M, Naka Y, Igarashi H, Tanuma M, Waschek JA, Ago Y, Tanaka KF, Hayata-Takano A, Nagayasu K, Shintani N, Hashimoto R, Kunii Y, Hino M, Matsumoto J, Yabe H, Nagai T, Fujita K, Matsuda T, Takuma K, Baba A, Hashimoto H

Neuron   94 ( 6 )   1085 - 1100.e6   2017.6（ ISSN:0896-6273 ）

精神科臨床と脳病理-精神科ブレインバンクへの期待- 生前登録制度に基づく精神疾患ブレインバンクの実践　当事者と研究者が協働する研究体制とは

國井 泰人, 松本 純弥, 長岡 敦子, 日野 瑞城, 丹羽 真一, 矢部 博興

精神神経学雑誌   ( 2017特別号 )   S410 - S410   2017.6（ ISSN:0033-2658 ）

Decreased 16:0/20:4-phosphatidylinositol level in the post-mortem prefrontal cortex of elderly patients with schizophrenia.

Matsumoto J, Nakanishi H, Kunii Y, Sugiura Y, Yuki D, Wada A, Hino M, Niwa SI, Kondo T, Waki M, Hayasaka T, Masaki N, Akatsu H, Hashizume Y, Yamamoto S, Sato S, Sasaki T, Setou M, Yabe H

Scientific reports   7   45050   2017.3

Downregulation of GNA13-ERK network in prefrontal cortex of schizophrenia brain identified by combined focused and targeted quantitative proteomics.

Hirayama-Kurogi M, Takizawa Y, Kunii Y, Matsumoto J, Wada A, Hino M, Akatsu H, Hashizume Y, Yamamoto S, Kondo T, Ito S, Tachikawa M, Niwa SI, Yabe H, Terasaki T, Setou M, Ohtsuki S

Journal of proteomics   158   31 - 42   2017.3（ ISSN:1874-3919 ）

Prominent increased calcineurin immunoreactivity in the superior temporal gyrus in schizophrenia: A postmortem study.

Wada A, Kunii Y, Matsumoto J, Hino M, Yang Q, Niwa SI, Yabe H

Psychiatry research   247   79 - 83   2017.1（ ISSN:0165-1781 ）

Decreased VEGFR2 expression and increased phosphorylated Akt1 in the prefrontal cortex of individuals with schizophrenia.

Hino M, Kunii Y, Matsumoto J, Wada A, Nagaoka A, Niwa S, Takahashi H, Kakita A, Akatsu H, Hashizume Y, Yamamoto S, Yabe H

Journal of psychiatric research   82   100 - 108   2016.11（ ISSN:0022-3956 ）

Decreased calcineurin immunoreactivity in the postmortem brain of a patient with schizophrenia who had been prescribed the calcineurin inhibitor, tacrolimus, for leukemia.

Wada A, Kunii Y, Matsumoto J, Hino M, Nagaoka A, Niwa S, Yabe H

Neuropsychiatric disease and treatment   12   1645 - 1650   2016（ ISSN:1176-6328 ）

統合失調症患者の前頭葉におけるタンパク質プロファイリングと変動する分子ネットワークの同定

平山 未央, 國井 泰人, 松本 純弥, 和田 明, 日野 瑞城, 矢部 博興, 丹羽 真一, 近藤 豪, 瀬藤 光利, 大槻 純男

日本生化学会大会・日本分子生物学会年会合同大会講演要旨集   88回・38回   [2LBA087] - [2LBA087]   2015.12

Influence of -141C Ins/Del Polymorphism in DRD2 Gene on Clinical Symptoms and Plasma Homovanillic Acid Levels in the Treatment of Schizophrenia With Aripiprazole.

Miura I, Kanno-Nozaki K, Hino M, Horikoshi S, Ota T, Mashiko H, Niwa S, Yabe H

Journal of clinical psychopharmacology   35 ( 3 )   333 - 4   2015.6（ ISSN:0271-0749 ）

Assessment of copy number variations in the brain genome of schizophrenia patients.

Sakai M, Watanabe Y, Someya T, Araki K, Shibuya M, Niizato K, Oshima K, Kunii Y, Yabe H, Matsumoto J, Wada A, Hino M, Hashimoto T, Hishimoto A, Kitamura N, Iritani S, Shirakawa O, Maeda K, Miyashita A, Niwa S, Takahashi H, Kakita A, Kuwano R, Nawa H

Molecular cytogenetics   8   46   2015

Elevated postmortem striatal t-DARPP expression in schizophrenia and associations with DRD2/ANKK1 polymorphism.

Kunii Y, Miura I, Matsumoto J, Hino M, Wada A, Niwa S, Nawa H, Sakai M, Someya T, Takahashi H, Kakita A, Yabe H

Progress in neuro-psychopharmacology & biological psychiatry   53   123 - 8   2014.8（ ISSN:0278-5846 ）

生前の精神症状情報を利用した精神疾患死後脳研究の展開

松本 純弥, 國井 泰人, 和田 明, 日野 瑞城, 池本 桂子, 瀬藤 光利, 丹羽 真一

福島医学雑誌   63 ( 3 )   173 - 174   2013.9（ ISSN:0016-2582 ）

X irradiation changes dendritic spine morphology and density through reduction of cytoskeletal proteins in mature neurons.

Shirai K, Mizui T, Suzuki Y, Okamoto M, Hanamura K, Yoshida Y, Hino M, Noda SE, Al-jahdari WS, Chakravarti A, Shirao T, Nakano T

Radiation research   179 ( 6 )   630 - 636   2013.6（ ISSN:0033-7587 ）

Increased ratio of calcineurin immunoreactive neurons in the caudate nucleus of patients with schizophrenia.

Wada A, Kunii Y, Ikemoto K, Yang Q, Hino M, Matsumoto J, Niwa S

Progress in neuro-psychopharmacology & biological psychiatry   37 ( 1 )   8 - 14   2012.4（ ISSN:0278-5846 ）

VAMP2 marks quiescent satellite cells and myotubes, but not activated myoblasts.

Tajika Y, Takahashi M, Hino M, Murakami T, Yorifuji H

Acta histochemica et cytochemica   43 ( 4 )   107 - 114   2010.8（ ISSN:1347-5800|0044-5991 ）

Stimulatory effects of arachidonic acid on myosin ATPase activity and contraction of smooth muscle via myosin motor domain.

Katayama T, Watanabe M, Tanaka H, Hino M, Miyakawa T, Ohki T, Ye LH, Xie C, Yoshiyama S, Nakamura A, Ishikawa R, Tanokura M, Oiwa K, Kohama K

American journal of physiology. Heart and circulatory physiology   298 ( 2 )   H505 - 14   2010.2（ ISSN:0363-6135 ）

Utilization of myosin and actin bundles for the transport of molecular cargo.

Takatsuki H, Rice KM, Asano S, Day BS, Hino M, Oiwa K, Ishikawa R, Hiratsuka Y, Uyeda TQ, Kohama K, Blough ER

Small (Weinheim an der Bergstrasse, Germany)   6 ( 3 )   452 - 457   2010.2（ ISSN:1613-6829|1613-6810 ）

Heavy ion irradiation induces autophagy in irradiated C2C12 myoblasts and their bystander cells.

Hino M, Hamada N, Tajika Y, Funayama T, Morimura Y, Sakashita T, Yokota Y, Fukamoto K, Mutou Y, Kobayashi Y, Yorifuji H

Journal of electron microscopy   59 ( 6 )   495 - 501   2010（ ISSN:1477-9986|0022-0744 ）

Insufficient membrane fusion in dysferlin-deficient muscle fibers after heavy-ion irradiation.

Hino M, Hamada N, Tajika Y, Funayama T, Morimura Y, Sakashita T, Yokota Y, Fukamoto K, Kobayashi Y, Yorifuji H

Cell structure and function   34 ( 1 )   11 - 5   2009（ ISSN:0386-7196 ）

骨格筋単離筋線維に与える重イオンマイクロビーム照射の影響の形態学的検討　筋ジストロフィー研究への応用をめざして

日野 瑞城, 和田 成一, 多鹿 友喜, 森村 吉博, 浜田 信行, 舟山 知夫, 坂下 哲哉, 柿崎 竹彦, 小林 泰彦, 依藤 宏

日本放射線影響学会大会講演要旨集   50回   152 - 152   2007.11（ ISSN:1347-8680 ）

Heavy ion microbeam irradiation induces ultrastructural changes in isolated single fibers of skeletal muscle.

Hino M, Wada S, Tajika Y, Morimura Y, Hamada N, Funayama T, Sakashita T, Kakizaki T, Kobayashi Y, Yorifuji H

Cell structure and function   32 ( 1 )   51 - 6   2007（ ISSN:0386-7196 ）

Calcium inhibition of Physarum myosin as examined by the recombinant heavy mero-myosin.

Kawamichi H, Zhang Y, Hino M, Nakamura A, Tanaka H, Farkas L, Nyitray L, Kohama K

Advances in experimental medicine and biology   592   265 - 72   2007（ ISSN:0065-2598 ）

Protective role of HSP27 against UVC-induced cell death in human cells.

Wano C, Kita K, Takahashi S, Sugaya S, Hino M, Hosoya H, Suzuki N

Experimental cell research   298 ( 2 )   584 - 92   2004.8（ ISSN:0014-4827 ）

Glycosylation of the alpha and beta tubulin by sialyloligosaccharides.

Hino M, Kijima-Suda I, Nagai Y, Hosoya H

Zoological science   20 ( 6 )   709 - 15   2003.6（ ISSN:0289-0003 ）

A new digalactosyl diacylglycerol from a cultured marine dinoflagellate Heterocapsa circularisquama.

Hiraga Y, Kaku K, Omoda D, Sugihara K, Hosoya H, Hino M

Journal of natural products   65 ( 10 )   1494 - 6   2002.10（ ISSN:0163-3864 ）

分子シャペロンHsp27の紫外線致死抵抗性への関与

和野 千枝子, 高橋 俊二, 日野 瑞城, 細谷 浩史, 喜多 和子, 鈴木 信夫

生化学   74 ( 8 )   1059 - 1059   2002.8（ ISSN:0037-1017 ）

Phosphorylation at threonine-18 in addition to phosphorylation at serine-19 on myosin-II regulatory light chain is a mitosis-specific event.

Gerashchenko BI, Ueda K, Hino M, Hosoya H

Cytometry   47 ( 3 )   150 - 7   2002.3（ ISSN:0196-4763 ）

Enrichment for late-telophase cell populations using flow cytometry.

Gerashchenko BI, Hino M, Hosoya H

Cytometry   41 ( 2 )   148 - 9   2000.10（ ISSN:0196-4763 ）

Erratum

Gerashchenko BI, Hino M, Hosoya H

Cytometry   41 ( 2 )   150   2000.10（ ISSN:0196-4763 ）

Small heat shock protein 27 (HSP27) associates with tubulin/microtubules in HeLa cells.

Hino M, Kurogi K, Okubo MA, Murata-Hori M, Hosoya H

Biochemical and biophysical research communications   271 ( 1 )   164 - 9   2000.4（ ISSN:0006-291X ）