Brain-specific glycosylation of protein tyrosine phosphatase receptor type Z (PTPRZ) marks a demyelination-associated astrocyte subtype.

Takahashi K, Kanekiyo K, Sakuda K, Muto Y, Iguchi M, Matsuda N, Hashimoto Y, Kanai K, Ogawa H, Hirase H, Kakita A, Bizen N, Takebayashi H, Kawaguchi Y, Uzuki M, Kitazume S

Journal of neurochemistry   166 ( 3 )   547 - 559   2023.8（ ISSN:0022-3042 ）

Verification of propagation hypothesis in patients with sporadic hand onset amyotrophic lateral sclerosis.

Iida S, Kanouchi T, Hattori T, Kanai K, Nakazato T, Hattori N, Yokota T

Acta neurologica Belgica   123 ( 4 )   1511 - 1517   2023.8（ ISSN:0300-9009 ）

Dynamics of AMPA receptors regulate epileptogenesis in patients with epilepsy.

Eiro T, Miyazaki T, Hatano M, Nakajima W, Arisawa T, Takada Y, Kimura K, Sano A, Nakano K, Mihara T, Takayama Y, Ikegaya N, Iwasaki M, Hishimoto A, Noda Y, Miyazaki T, Uchida H, Tani H, Nagai N, Koizumi T, Nakajima S, Mimura M, Matsuda N, Kanai K, Takahashi K, Ito H, Hirano Y, Kimura Y, Matsumoto R, Ikeda A, Takahashi T

Cell reports. Medicine   4 ( 5 )   101020   2023.5

Genetic factors affecting survival in Japanese patients with sporadic amyotrophic lateral sclerosis: a genome-wide association study and verification in iPSC-derived motor neurons from patients.

Nakamura R, Tohnai G, Nakatochi M, Atsuta N, Watanabe H, Ito D, Katsuno M, Hirakawa A, Izumi Y, Morita M, Hirayama T, Kano O, Kanai K, Hattori N, Taniguchi A, Suzuki N, Aoki M, Iwata I, Yabe I, Shibuya K, Kuwabara S, Oda M, Hashimoto R, Aiba I, Ishihara T, Onodera O, Yamashita T, Abe K, Mizoguchi K, Shimizu T, Ikeda Y, Yokota T, Hasegawa K, Tanaka F, Nakashima K, Kaji R, Niwa JI, Doyu M, Terao C, Ikegawa S, Fujimori K, Nakamura S, Ozawa F, Morimoto S, Onodera K, Ito T, Okada Y, Okano H, Sobue G

Journal of neurology, neurosurgery, and psychiatry   2023.5

[A case of recurrent cerebral infarction in an adult patient with false Taussig-Bing anomaly].

Akanuma H, Matsuda N, Itagaki Y, Yoshida K, Kanai K

Rinsho shinkeigaku = Clinical neurology   62 ( 12 )   940 - 945   2022.12（ ISSN:0009-918X ）

Mollaret Meningitis Caused by Varicella-Zoster Virus: A Case Report.

Akanuma H, Ueno SI, Tanaka S, Matsuda N, Kanai K

Cureus   14 ( 11 )   e31834   2022.11（ ISSN:2168-8184 ）

Patients with biallelic GGC repeat expansions in NOTCH2NLC exhibiting a typical neuronal intranuclear inclusion disease phenotype.

Kameyama S, Mizuguchi T, Doi H, Koyano S, Okubo M, Tada M, Shimizu H, Fukuda H, Tsuchida N, Uchiyama Y, Koshimizu E, Hamanaka K, Fujita A, Misawa K, Miyatake S, Kanai K, Tanaka F, Matsumoto N

Genomics   114 ( 5 )   110469   2022.9（ ISSN:0888-7543 ）

[Oculomotor nerve palsy with preserved pupillary reaction in two cases of neurolymphomatosis].

Hattori K, Matsuda N, Yoshizawa M, Ugawa Y, Kanai K

Rinsho shinkeigaku = Clinical neurology   62 ( 7 )   552 - 557   2022.7（ ISSN:0009-918X ）

Plasma taurine is an axonal excitability-translatable biomarker for amyotrophic lateral sclerosis.

Nakazato T, Kanai K, Kataura T, Nojiri S, Hattori N, Saiki S

Scientific reports   12 ( 1 )   9155   2022.6

Efficacy and Safety of Ultrahigh-Dose Methylcobalamin in Early-Stage Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial.

Oki R, Izumi Y, Fujita K, Miyamoto R, Nodera H, Sato Y, Sakaguchi S, Nokihara H, Kanai K, Tsunemi T, Hattori N, Hatanaka Y, Sonoo M, Atsuta N, Sobue G, Shimizu T, Shibuya K, Ikeda K, Kano O, Nishinaka K, Kojima Y, Oda M, Komai K, Kikuchi H, Kohara N, Urushitani M, Nakayama Y, Ito H, Nagai M, Nishiyama K, Kuzume D, Shimohama S, Shimohata T, Abe K, Ishihara T, Onodera O, Isose S, Araki N, Morita M, Noda K, Toda T, Maruyama H, Furuya H, Teramukai S, Kagimura T, Noma K, Yanagawa H, Kuwabara S, Kaji R, Japan Early-Stage Trial of Ultrahigh-Dose Methylcobalamin for ALS (JETALS) Collaborators.

JAMA neurology   79 ( 6 )   575 - 583   2022.6（ ISSN:2168-6149 ）

Mutation screening of the DNAJC7 gene in Japanese patients with sporadic amyotrophic lateral sclerosis.

Tohnai G, Nakamura R, Atsuta N, Nakatochi M, Hayashi N, Ito D, Watanabe H, Watanabe H, Katsuno M, Izumi Y, Taniguchi A, Kanai K, Morita M, Kano O, Kuwabara S, Oda M, Abe K, Aoki M, Aiba I, Okamoto K, Mizoguchi K, Ishihara T, Kawata A, Yokota T, Hasegawa K, Nagano I, Yabe I, Tanaka F, Kuru S, Hattori N, Nakashima K, Kaji R, Sobue G, Japanese Consortium for Amyotrophic Lateral Sclerosis Research (JaCALS).

Neurobiology of aging   113   131 - 136   2022.5（ ISSN:0197-4580 ）

Subclinical involvement of the trunk muscles in idiopathic inflammatory myopathies.

Matsuda N, Kobayashi S, Hasegawa O, Yoshida K, Kubo H, Ugawa Y, Kanai K

Acta radiologica open   11 ( 2 )   20584601221075796   2022.2

Candida brain abscesses in a patient with anorexia nervosa receiving total parenteral nutrition.

Yoshida K, Matsuda N, Sato T, Watanabe T, Nakamura K, Saito K, Kanai K, Ugawa Y

Clinical neurology and neurosurgery   212   107058   2022.1（ ISSN:0303-8467 ）

Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with small cell lung cancer and cytotoxic T-cell-mediated pathology: Case report.

Akanuma H, Iizuka T, Abe D, Yoshida K, Matsuda N, Sugimoto K, Hashimoto Y, Kanai K

Frontiers in immunology   13   952868   2022

Perceptual uncertainty modulates auditory statistical learning: A magnetoencephalography study.

Okano T, Daikoku T, Ugawa Y, Kanai K, Yumoto M

International journal of psychophysiology : official journal of the International Organization of Psychophysiology   168   65 - 71   2021.10（ ISSN:0167-8760 ）

MRI mapping of muscle denervation in mononeuropathy multiplex due to eosinophilic granulomatosis with polyangiitis

Matsuda N., Abe D., Fujita Y., Kanai K.

Neurology and Clinical Neuroscience   9 ( 5 )   406 - 407   2021.9

Meningoencephalitis in relapsing polychondritis: A case report.

Matsumoto H, Tokimura R, Fujita Y, Matsuoka N, Asano T, Sato S, Temmoku J, Yashiro-Furuya M, Yoshida K, Takahashi R, Tanaka S, Itagaki Y, Honma M, Matsuda N, Watanabe H, Migita K, Kanai K

Medicine   100 ( 24 )   e26315   2021.6（ ISSN:0025-7974 ）

Detection of NUCB2/nesfatin-1 in cerebrospinal fluid of multiple sclerosis patients.

Shimizu M, Manome T, Kumami M, Matsumura K, Kanai K, Shimomura K, Maejima Y

Aging   12 ( 23 )   24134 - 24140   2020.12

A multi-ethnic meta-analysis identifies novel genes, including ACSL5, associated with amyotrophic lateral sclerosis.

Nakamura R, Misawa K, Tohnai G, Nakatochi M, Furuhashi S, Atsuta N, Hayashi N, Yokoi D, Watanabe H, Watanabe H, Katsuno M, Izumi Y, Kanai K, Hattori N, Morita M, Taniguchi A, Kano O, Oda M, Shibuya K, Kuwabara S, Suzuki N, Aoki M, Ohta Y, Yamashita T, Abe K, Hashimoto R, Aiba I, Okamoto K, Mizoguchi K, Hasegawa K, Okada Y, Ishihara T, Onodera O, Nakashima K, Kaji R, Kamatani Y, Ikegawa S, Momozawa Y, Kubo M, Ishida N, Minegishi N, Nagasaki M, Sobue G

Communications biology   3 ( 1 )   526   2020.9

Genetic and functional analysis of KIF5A variants in Japanese patients with sporadic amyotrophic lateral sclerosis.

Nakamura R, Tohnai G, Atsuta N, Nakatochi M, Hayashi N, Watanabe H, Yokoi D, Watanabe H, Katsuno M, Izumi Y, Taniguchi A, Kanai K, Morita M, Kano O, Kuwabara S, Oda M, Abe K, Aoki M, Aiba I, Okamoto K, Mizoguchi K, Hattori N, Nakashima K, Kaji R, Sobue G, Japanese Consortium for Amyotrophic Lateral Sclerosis Research (JaCALS).

Neurobiology of aging   2020.7（ ISSN:0197-4580 ）

The identified clinical features of Parkinson's disease in homo-, heterozygous and digenic variants of PINK1.

Hayashida A, Li Y, Yoshino H, Daida K, Ikeda A, Ogaki K, Fuse A, Mori A, Takanashi M, Nakahara T, Yoritaka A, Tomizawa Y, Furukawa Y, Kanai K, Nakayama Y, Ito H, Ogino M, Hattori Y, Hattori T, Ichinose Y, Takiyama Y, Saito T, Kimura T, Aizawa H, Shoji H, Mizuno Y, Matsushita T, Sato M, Sekijima Y, Morita M, Iwasaki A, Kusaka H, Tada M, Tanaka F, Sakiyama Y, Fujimoto T, Nagara Y, Kashihara K, Todo H, Nakao K, Tsuruta K, Yoshikawa M, Hara H, Yokote H, Murase N, Nakamagoe K, Tamaoka A, Takamiya M, Morimoto N, Nokura K, Kako T, Funayama M, Nishioka K, Hattori N

Neurobiology of aging   2020.7（ ISSN:0197-4580 ）

A Retrospective Imaging Evaluation of Presynaptic Dopaminergic Degeneration in Multiple System Atrophy with Levodopa Induced Dyskinesia.

Ueno SI, Oyama G, Kanai K, Hatano T, Shimo Y, Hattori N

Tremor and other hyperkinetic movements (New York, N.Y.)   10   6   2020.6

Abnormal evoked potentials in autoimmune glial fibrillary acidic protein astrocytopathy.

Tokimura R, Matsuda N, Kobayashi S, Kimura A, Kanai K

eNeurologicalSci   18   100229   2020.3

Prognosis of amyotrophic lateral sclerosis patients undergoing tracheostomy invasive ventilation therapy in Japan.

Hayashi N, Atsuta N, Yokoi D, Nakamura R, Nakatochi M, Katsuno M, Izumi Y, Kanai K, Hattori N, Taniguchi A, Morita M, Kano O, Shibuya K, Kuwabara S, Suzuki N, Aoki M, Aiba I, Mizoguchi K, Oda M, Kaji R, Sobue G

Journal of neurology, neurosurgery, and psychiatry   2020.1（ ISSN:0022-3050 ）

MRI Mapping of Muscle Denervation in Metastatic Myelopathy.

Matsuda N, Minemura H, Kobayashi S, Kanai K

Internal medicine (Tokyo, Japan)   2020.1（ ISSN:0918-2918 ）

Arylsulfatase A, a genetic modifier of Parkinson’s disease, is an α-synuclein chaperone

Lee J., Kanai K., Suzuki M., Kim W., Yoo H., Fu Y., Kim D., Jung B., Choi M., Oh K., Li Y., Nakatani M., Nakazato T., Sekimoto S., Funayama M., Yoshino H., Kubo S., Nishioka K., Sakai R., Ueyama M., Mochizuki H., Lee H., Sardi S., Halliday G., Nagai Y., Lee P., Hattori N., Lee S.

Brain   142 ( 9 )   2845 - 2859   2019.9（ ISSN:00068950 ）

Pembrolizumab-related systemic myositis involving ocular and hindneck muscles resembling myasthenic gravis: a case report.

Kamo H, Hatano T, Kanai K, Aoki N, Kamiyama D, Yokoyama K, Takanashi M, Yamashita Y, Shimo Y, Hattori N

BMC neurology   19 ( 1 )   184   2019.8

Efficacy and safety of leuprorelin acetate for subjects with spinal and bulbar muscular atrophy: pooled analyses of two randomized-controlled trials

Hashizume A., Katsuno M., Suzuki K., Banno H., Takeuchi Y., Kawashima M., Suga N., Mano T., Araki A., Hijikata Y., Hirakawa A., Sobue G., Sasaki H., Aoki M., Nakano I., Ito S., Mizusawa H., Yamamoto T., Hasegawa K., Miyajima H., Sobue G., Kanda N., Nakajima K., Tsujino A., Uchino M., Morita M., Kanai K., Yamamoto T., Mizusawa H., Yamamoto T., Sobue G.

Journal of Neurology   266 ( 5 )   1211 - 1221   2019.5（ ISSN:03405354 ）

Restabilization treatment after intravenous immunoglobulin withdrawal in chronic inflammatory demyelinating polyneuropathy: Results from the pre-randomization phase of the Polyneuropathy And Treatment with Hizentra study

Mielke O., Bril V., Cornblath D., Lawo J., van Geloven N., Hartung H., Lewis R., Merkies I., Sobue G., Durn B., Shebl A., van Schaik I., Sabet A., George K., Roberts L., Carne R., Blum S., Henderson R., Van Damme P., Demeestere J., Larue S., D'Amour C., Kunc P., Valis M., Sussova J., Kalous T., Talab R., Bednar M., Toomsoo T., Rubanovits I., Gross-Paju K., Sorro U., Saarela M., Auranen M., Pouget J., Attarian S., Le Masson G., Wielanek-Bachelet A., Desnuelle C., Delmont E., Clavelou P., Aufauvre D., Schmidt J., Zschuentzsch J., Sommer C., Kramer D., Hoffmann O., Goerlitz C., Haas J., Chatzopoulos M., Yoon R., Gold R., Berlit P., Jaspert-Grehl A., Liebetanz D., Kutschenko A., Stangel M., Trebst C., Baum P., Bergh F., Klehmet J., Meisel A., Klostermann F., Oechtering J., Lehmann H., Schroeter M., Hagenacker T., Mueller D., Sperfeld A., Bethke F., Drory V., Algom A., Yarnitsky D., Murinson B., Di Muzio A., Ciccocioppo F., Sorbi S., Mata S., Schenone A., Grandis M., Lauria G., Cazzato D., Antonini G., Morino S., Cocito D., Zibetti M., Yokota T., Ohkubo T., Kanda T., Kawai M., Kaida K., Onoue H., Kuwabara S., Mori M., Iijima M., Ohyama K., Baba M., Tomiyama M., Nishiyama K., Akutsu T.

Journal of the Peripheral Nervous System   24 ( 1 )   72 - 79   2019.3（ ISSN:10859489 ）

Efficacy and safety of IVIG in CIDP: Combined data of the PRIMA and PATH studies

Merkies I., van Schaik I., Léger J., Bril V., van Geloven N., Hartung H., Lewis R., Sobue G., Lawo J., Durn B., Cornblath D., De Bleecker J., Sommer C., Robberecht W., Saarela M., Kamienowski J., Stelmasiak Z., Tackenberg B., Mielke O., Sabet A., George K., Roberts L., Carne R., Blum S., Henderson R., Van Damme P., Demeestere J., Larue S., D'Amour C., Kunc P., Valis M., Sussova J., Kalous T., Talab R., Bednar M., Toomsoo T., Rubanovits I., Gross-Paju K., Sorro U., Saarela M., Auranen M., Pouget J., Attarian S., Masson G., Wielanek-Bachelet A., Desnuelle C., Delmont E., Clavelou P., Aufauvre D., Schmidt J., Zschuentzsch J., Sommer C., Kramer D., Hoffmann O., Goerlitz C., Haas J., Chatzopoulos M., Yoon R., Gold R., Berlit P., Jaspert-Grehl A., Liebetanz D., Kutschenko A., Stangel M., Trebst C., Baum P., Bergh F., Klehmet J., Meisel A., Klostermann F., Oechtering J., Lehmann H., Schroeter M., Hagenacker T., Mueller D., Sperfeld A., Bethke F., Drory V., Algom A., Yarnitsky D., Murinson B., Di Muzio A., Ciccocioppo F., Sorbi S., Mata S., Schenone A., Grandis M., Lauria G., Cazzato D., Antonini G., Morino S., Cocito D., Zibetti M., Yokota T., Ohkubo T., Kanda T., Kawai M., Kaida K., Onoue H., Kuwabara S.

Journal of the Peripheral Nervous System   24 ( 1 )   48 - 55   2019.3（ ISSN:10859489 ）

The Japanese Early-Stage Trial of High-Dose Methylcobalamin for Amyotrophic Lateral Sclerosis (JETALS): Protocol for a Randomized Controlled Trial.

Oki R, Izumi Y, Nodera H, Sato Y, Nokihara H, Kanai K, Sonoo M, Urushitani M, Nishinaka K, Atsuta N, Kohara N, Shimizu T, Kikuchi H, Oda M, Ikeda K, Nagai M, Komai K, Kojima Y, Kuzume D, Isose S, Shimohama S, Abe K, Ito H, Noda K, Ishihara T, Morita M, Shimohata T, Teramukai S, Kagimura T, Noma K, Yanagawa H, Kuwabara S, Kaji R, JETALS.

JMIR research protocols   7 ( 12 )   e12046   2018.12

Myalgia caused by chronic myositis associated with plasmacytosis: A case report

Hatano T., Takanashi M., Tsuchihashi H., Ueno S., Hayashida A., Tsukune Y., Kanai K., Shimo Y., Hattori N.

BMC Neurology   18 ( 1 )   2018.8

COQ2 variants in Parkinson’s disease and multiple system atrophy

Mikasa M., Kanai K., Li Y., Yoshino H., Mogushi K., Hayashida A., Ikeda A., Kawajiri S., Okuma Y., Kashihara K., Sato T., Kondo H., Funayama M., Nishioka K., Hattori N.

Journal of Neural Transmission   125 ( 6 )   937 - 944   2018.6（ ISSN:03009564 ）

Isaacs syndrome: A slow potassium channelopathy caused by autoantibodies?

Nakazato T., Tsuji Y., Kanai K., Noto Y., Hoshino Y., Yamashiro K., Yokoyama K., Nishioka K., Shimo Y., Watanabe O., Mizuno T., Hattori N.

Clinical Neurophysiology   129 ( 5 )   956 - 958   2018.5（ ISSN:13882457 ）

【パーキンソン病(第2版)-基礎・臨床研究のアップデート-】 検査・診断　関連疾患　多系統萎縮症

金井 数明, 服部 信孝

日本臨床   76 ( 増刊4 パーキンソン病 )   344 - 350   2018.5（ ISSN:0047-1852 ）

A Japanese family with mutation in the proteinase inhibitor 12 L47P gene: A case report

Amano-Takeshige H., Oyama G., Kanai K., Miyagawa T., Mitsui J., Ugawa Y., Tsuji S., Hattori N.

Journal of the Neurological Sciences   384   126 - 128   2018.1（ ISSN:0022510X ）

Subcutaneous immunoglobulin for maintenance treatment in chronic inflammatory demyelinating polyneuropathy (PATH): a randomised, double-blind, placebo-controlled, phase 3 trial

van Schaik I., Bril V., van Geloven N., Hartung H., Lewis R., Sobue G., Lawo J., Praus M., Mielke O., Durn B., Cornblath D., Merkies I., Sabet A., George K., Roberts L., Carne R., Blum S., Henderson R., Van Damme P., Demeestere J., Larue S., D'Amour C., Breiner A., Kunc P., Valis M., Sussova J., Kalous T., Talab R., Bednar M., Toomsoo T., Rubanovits I., Gross-Paju K., Sorro U., Saarela M., Auranen M., Pouget J., Attarian S., Le Masson G., Wielanek-Bachelet A., Desnuelle C., Delmont E., Clavelou P., Aufauvre D., Schmidt J., Zschuentssch J., Sommer C., Kramer D., Hoffmann O., Goerlitz C., Haas J., Chatzopoulos M., Yoon R., Gold R., Berlit P., Jaspert-Grehl A., Liebetanz D., Kutschenko A., Stangel M., Trebst C., Baum P., Bergh F., Klehmet J., Meisel A., Klostermann F., Oechtering J., Lehmann H., Schroeter M., Hagenacker T., Mueller D., Sperfeld A., Bethke F., Drory V., Algom A., Yarnitsky D., Murinson B., Di Muzio A., Ciccocioppo F., Sorbi S., Mata S., Schenone A., Grandis M., Lauria G., Cazzato D., Antonini G., Morino S., Cocito D., Zibetti M., Yokota T., Ohkubo T., Kanda T., Kawai M., Kaida K., Onoue H., Kuwabara S., Mori M., Iijima M., Ohyama K., Baba M., Tomiyama M.

The Lancet Neurology   17 ( 1 )   35 - 46   2018.1（ ISSN:14744422 ）

Paraneoplastic neuromyotonia due to lung carcinoma and invisible muscle cramps evaluated using ultrasonography

Nishioka K., Kanai K., Hattori N.

Journal of Neuro-Oncology   134 ( 1 )   243 - 244   2017.8（ ISSN:0167594X ）

Parkinsonism in a patient with valosin-containing protein gene mutation showing: a case report

Fujimaki M., Kanai K., Funabe S., Takanashi M., Yokoyama K., Li Y., Hattori N.

Journal of Neurology   264 ( 6 )   1284 - 1286   2017.6（ ISSN:03405354 ）

Demyelinating peripheral neuropathy due to renal cell carcinoma

Nishioka K., Fujimaki M., Kanai K., Ishiguro Y., Nakazato T., Tanaka R., Yokoyama K., Hattori N.

Internal Medicine   56 ( 1 )   101 - 104   2017.1（ ISSN:09182918 ）

Case of Morvan syndrome with anti-Ma2/Ta antibodies

Nishioka K., Hoshino Y., Kanai K., Ueno S., Nakazato T., Takanashi M., Tanaka R., Yokoyama K., Arimura K., Kuwabara S., Hattori N.

Clinical and Experimental Neuroimmunology   7 ( 4 )   369 - 372   2016.11

Utility of ultrasonography in evaluating muscle contractions in stiff-person syndrome

Hoshino Y., Nishioka K., Kanai K., Tanaka R., Nagaoka M., Kuwabara S., Hattori N.

Journal of the Neurological Sciences   367   361 - 362   2016.8（ ISSN:0022510X ）

A rapid functional decline type of amyotrophic lateral sclerosis is linked to low expression of TTN

Watanabe H., Atsuta N., Hirakawa A., Nakamura R., Nakatochi M., Ishigaki S., Iida A., Ikegawa S., Kubo M., Yokoi D., Watanabe H., Ito M., Katsuno M., Izumi Y., Morita M., Kanai K., Taniguchi A., Aiba I., Abe K., Mizoguchi K., Oda M., Kano O., Okamoto K., Kuwabara S., Hasegawa K., Imai T., Kawata A., Aoki M., Tsuji S., Nakashima K., Kaji R., Sobue G.

Journal of Neurology, Neurosurgery and Psychiatry   87 ( 8 )   851 - 858   2016.1（ ISSN:00223050 ）

Variants associated with Gaucher disease in multiple system atrophy.

Mitsui J, Matsukawa T, Sasaki H, Yabe I, Matsushima M, Dürr A, Brice A, Takashima H, Kikuchi A, Aoki M, Ishiura H, Yasuda T, Date H, Ahsan B, Iwata A, Goto J, Ichikawa Y, Nakahara Y, Momose Y, Takahashi Y, Hara K, Kakita A, Yamada M, Takahashi H, Onodera O, Nishizawa M, Watanabe H, Ito M, Sobue G, Ishikawa K, Mizusawa H, Kanai K, Hattori T, Kuwabara S, Arai K, Koyano S, Kuroiwa Y, Hasegawa K, Yuasa T, Yasui K, Nakashima K, Ito H, Izumi Y, Kaji R, Kato T, Kusunoki S, Osaki Y, Horiuchi M, Kondo T, Murayama S, Hattori N, Yamamoto M, Murata M, Satake W, Toda T, Filla A, Klockgether T, Wüllner U, Nicholson G, Gilman S, Tanner CM, Kukull WA, Stern MB, Lee VM, Trojanowski JQ, Masliah E, Low PA, Sandroni P, Ozelius LJ, Foroud T, Tsuji S

Annals of clinical and translational neurology   2 ( 4 )   417 - 26   2015.4

A 3-year cohort study of the natural history of spinocerebellar ataxia type 6 in Japan

Yasui K., Yabe I., Yoshida K., Kanai K., Arai K., Ito M., Onodera O., Koyano S., Isozaki E., Sawai S., Adachi Y., Sasaki H., Kuwabara S., Hattori T., Sobue G., Mizusawa H., Tsuji S., Nishizawa M., Nakashima K.

Orphanet Journal of Rare Diseases   9 ( 1 )   2014.7

病気について知りたい!臨床講座　パーキンソン病

金井 数明, 服部 信孝

PharmaTribune   6 ( 6 )   23 - 33   2014.6（ ISSN:1883-4043 ）

【神経症候群(第2版)-その他の神経疾患を含めて-】 変性疾患　脊髄小脳変性症　常染色体優性遺伝性脊髄小脳失調症　ポリグルタミン病　Machado-Joseph病(SCA3)

金井 数明, 服部 信孝

日本臨床   別冊 ( 神経症候群II )   345 - 349   2014.3（ ISSN:0047-1852 ）

Prominent fatigue in spinal muscular atrophy and spinal and bulbar muscular atrophy: Evidence of activity-dependent conduction block

Noto Y., Misawa S., Mori M., Kawaguchi N., Kanai K., Shibuya K., Isose S., Nasu S., Sekiguchi Y., Beppu M., Ohmori S., Nakagawa M., Kuwabara S.

Clinical Neurophysiology   124 ( 9 )   1893 - 1898   2013.9（ ISSN:13882457 ）

POEMS syndrome and interleukin-12: Missing piece in the pathogenesis of peripheral nerve demyelination

Kanai K., Sawai S., Kuwabara S.

Clinical and Experimental Neuroimmunology   4 ( 1 )   16 - 17   2013.6

【神経内科検査のみかた-脳のイメージングを中心に】 どんなイメージがあるの?　脳波

金井 数明

Modern Physician   33 ( 5 )   603 - 606   2013.5（ ISSN:0913-7963 ）

【神経内科検査のみかた-脳のイメージングを中心に】 神経内科のトピックス　新しい抗てんかん薬の使い方

金井 数明

Modern Physician   33 ( 5 )   687 - 690   2013.5（ ISSN:0913-7963 ）

Mutations in COQ2 in familial and sporadic multiple-system atrophy the multiple-system atrophy research collaboration

Mitsui J., Matsukawa T., Ishiura H., Fukuda Y., Ichikawa Y., Date H., Ahsan B., Nakahara Y., Momose Y., Takahashi Y., Iwata A., Goto J., Yamamoto Y., Komata M., Shirahige K., Hara K., Kakita A., Yamada M., Takahashi H., Onodera O., Nishizawa M., Takashima H., Kuwano R., Watanabe H., Ito M., Sobue G., Soma H., Yabe I., Sasaki H., Aoki M., Ishikawa K., Mizusawa H., Kanai K., Hattori T., Kuwabara S., Arai K., Koyano S., Kuroiwa Y., Hasegawa K., Yuasa T., Yasui K., Nakashima K., Ito H., Izumi Y., Kaji R., Kato T., Kusunoki S., Osaki Y., Horiuchi M., Kondo T., Murayama S., Hattori N., Yamamoto M., Murata M., Satake W., Toda T., Dürr A., Brice A., Filla A., Klockgether T., Wallner U., Nicholson G., Gilman S., Shults C., Tanner C., Kukull W., Lee V., Masliah E., Low P., Sandroni P., Trojanowski J., Ozelius L., Foroud T., Tsuji S.

New England Journal of Medicine   369 ( 3 )   233 - 244   2013.1（ ISSN:00284793 ）

Japanese amyotrophic lateral sclerosis patients with GGGGCC hexanucleotide repeat expansion in C9ORF72

Konno T., Shiga A., Tsujino A., Sugai A., Kato T., Kanai K., Yokoseki A., Eguchi H., Kuwabara S., Nishizawa M., Takahashi H., Onodera O.

Journal of Neurology, Neurosurgery and Psychiatry   84 ( 4 )   398 - 401   2013.1（ ISSN:00223050 ）

Multiple angiogenetic factors are upregulated in POEMS syndrome

Yamada Y., Sawai S., Misawa S., Kanai K., Shibuya K., Mori M., Moriya J., Sogawa K., Yamamoto H., Beppu M., Taniguchi J., Nakaseko C., Nomura F., Kuwabara S.

Annals of Hematology   92 ( 2 )   245 - 248   2013.1（ ISSN:09395555 ）

Split hand syndrome in amyotrophic lateral sclerosis: Different excitability changes in the thenar and hypothenar motor axons

Shibuya K., Misawa S., Nasu S., Sekiguchi Y., Mitsuma S., Beppu M., Ohmori S., Iwai Y., Ito S., Kanai K., Sato Y., Kuwabara S.

Journal of Neurology, Neurosurgery and Psychiatry   84 ( 9 )   969 - 972   2013.1（ ISSN:00223050 ）

The contributions to clinical neurology of the axonal excitability property measurements

Kanai K.

Clinical Neurology   52 ( 11 )   1256 - 1258   2012.12（ ISSN:0009918X ）

Pentanucleotide repeat-primed PCR for genetic diagnosis of spinocerebellar ataxia type 31

Ishige T., Sawai S., Itoga S., Sato K., Utsuno E., Beppu M., Kanai K., Nishimura M., Matsushita K., Kuwabara S., Nomura F.

Journal of Human Genetics   57 ( 12 )   807 - 808   2012.12（ ISSN:14345161 ）

Mobilization of PBSCs in poor mobilizers with POEMS syndrome using G-CSF with plerixafor

Shimizu N., Sakaida E., Ohwada C., Takeuchi M., Kawaguchi T., Tsukamoto S., Sakai S., Takeda Y., Sugita Y., Yokote K., Iseki T., Isose S., Kanai K., Misawa S., Kuwabara S., Nakaseko C.

Bone Marrow Transplantation   47 ( 12 )   1587 - 1588   2012.12（ ISSN:02683369 ）

Cutaneous sympathetic dysfunction in patients with Machado-Joseph disease

Yamanaka Y., Asahina M., Akaogi Y., Fujinuma Y., Katagiri A., Kanai K., Kuwabara S.

Cerebellum   11 ( 4 )   1057 - 1060   2012.12（ ISSN:14734222 ）

電気診断の復権 軸索興奮特性測定の臨床への貢献

金井 数明

臨床神経学   52 ( 11 )   1256 - 1258   2012.11（ ISSN:0009-918X ）

A case of adult-onset alexander disease featuring severe atrophy of the medulla oblongata and upper cervical cord on magnetic resonance imaging

Yonezu T., Ito S., Kanai K., Masuda S., Shibuya K., Kuwabara S.

Case Reports in Neurology   4 ( 3 )   202 - 206   2012.9

Markedly upregulated serum interleukin-12 as a novel biomarker in POEMS syndrome

Kanai K., Sawai S., Sogawa K., Mori M., Misawa S., Shibuya K., Isose S., Fujimaki Y., Noto Y., Sekiguchi Y., Nasu S., Nakaseko C., Takano S., Yoshitomi H., Miyazaki M., Nomura F., Kuwabara S.

Neurology   79 ( 6 )   575 - 582   2012.8（ ISSN:00283878 ）

A case of adult onset vanishing white matter disease developed after minor head trauma

Koga S., Sekiguchi Y., Kanai K., Mutoh M., Kuwabara S.

Clinical Neurology   52 ( 8 )   561 - 566   2012.8（ ISSN:0009918X ）

Motor axonal excitability properties are strong predictors for survival in amyotrophic lateral sclerosis

Kanai K., Shibuya K., Sato Y., Misawa S., Nasu S., Sekiguchi Y., Mitsuma S., Isose S., Fujimaki Y., Ohmori S., Koga S., Kuwabara S.

Journal of Neurology, Neurosurgery and Psychiatry   83 ( 7 )   734 - 738   2012.7（ ISSN:00223050 ）

Flattened facial colliculus on magnetic resonance imaging in Machado-Joseph disease

Ogawa Y., Ito S., Makino T., Kanai K., Arai K., Kuwabara S.

Movement Disorders   27 ( 8 )   1041 - 1046   2012.7（ ISSN:08853185 ）

Factors associated with the efficiency of PBSC collection in POEMS syndrome patients undergoing autologous PBSC transplantation

Shimizu N., Nakaseko C., Sakaida E., Ohwada C., Takeuchi M., Kawaguchi T., Tsukamoto S., Sakai S., Takeda Y., Abe D., Yokote K., Iseki T., Kanai K., Misawa S., Kuwabara S.

Bone Marrow Transplantation   47 ( 7 )   1010 - 1012   2012.7（ ISSN:02683369 ）

Differences in excitability between median and superficial radial sensory axons

Fujimaki Y., Kanai K., Misawa S., Shibuya K., Isose S., Nasu S., Sekiguchi Y., Ohmori S., Noto Y., Kugio Y., Shimizu T., Matsubara S., Lin C., Kuwabara S.

Clinical Neurophysiology   123 ( 7 )   1440 - 1445   2012.7（ ISSN:13882457 ）

Different neurological and physiological profiles in POEMS syndrome and chronic inflammatory demyelinating polyneuropathy

Nasu S., Misawa S., Sekiguchi Y., Shibuya K., Kanai K., Fujimaki Y., Ohmori S., Mitsuma S., Koga S., Kuwabara S.

Journal of Neurology, Neurosurgery and Psychiatry   83 ( 5 )   476 - 479   2012.5（ ISSN:00223050 ）

Mutations in PRRT2 responsible for paroxysmal kinesigenic dyskinesias also cause benign familial infantile convulsions

Ono S., Yoshiura K., Kinoshita A., Kikuchi T., Nakane Y., Kato N., Sadamatsu M., Konishi T., Nagamitsu S., Matsuura M., Yasuda A., Komine M., Kanai K., Inoue T., Osamura T., Saito K., Hirose S., Koide H., Tomita H., Ozawa H., Niikawa N., Kurotaki N.

Journal of Human Genetics   57 ( 5 )   338 - 341   2012.5（ ISSN:14345161 ）

【脊髄小脳変性症(SCD)のUp-To-Date】 常染色体優性遺伝性SCD　Machado-Joseph病(MJD)

金井 数明

最新医学   67 ( 5 )   1077 - 1081   2012.5（ ISSN:0370-8241 ）

Awaji ALS criteria increase the diagnostic sensitivity in patients with bulbar onset

Noto Y., Misawa S., Kanai K., Shibuya K., Isose S., Nasu S., Sekiguchi Y., Fujimaki Y., Nakagawa M., Kuwabara S.

Clinical Neurophysiology   123 ( 2 )   382 - 385   2012.2（ ISSN:13882457 ）

Antiganglioside antibodies are associated with axonal Guillain-Barré syndrome: A Japanese-Italian collaborative study

Sekiguchi Y., Uncini A., Yuki N., Misawa S., Notturno F., Nasu S., Kanai K., Noto Y., Fujimaki Y., Shibuya K., Ohmori S., Sato Y., Kuwabara S.

Journal of Neurology, Neurosurgery and Psychiatry   83 ( 1 )   23 - 28   2012.1（ ISSN:00223050 ）

Non-human primate model of amyotrophic lateral sclerosis with cytoplasmic mislocalization of TDP-43

Uchida A., Sasaguri H., Kimura N., Tajiri M., Ohkubo T., Ono F., Sakaue F., Kanai K., Hirai T., Sano T., Shibuya K., Kobayashi M., Yamamoto M., Yokota S., Kubodera T., Tomori M., Sakaki K., Enomoto M., Hirai Y., Kumagai J., Yasutomi Y., Mochizuki H., Kuwabara S., Uchihara T., Mizusawa H., Yokota T.

Brain   135 ( 3 )   833 - 846   2012.1（ ISSN:00068950 ）

Motor axonal excitability properties are strong predictors for survival in amyotrophic lateral sclerosis

Kanai K., Shibuya K., Kuwabara S.

Clinical Neurology   51 ( 11 )   1118 - 1119   2011.12（ ISSN:0009918X ）

Markedly reduced axonal potassium channel expression in human sporadic amyotrophic lateral sclerosis: An immunohistochemical study

Shibuya K., Misawa S., Arai K., Nakata M., Kanai K., Yoshiyama Y., Ito K., Isose S., Noto Y., Nasu S., Sekiguchi Y., Fujimaki Y., Ohmori S., Kitamura H., Sato Y., Kuwabara S.

Experimental Neurology   232 ( 2 )   149 - 153   2011.12（ ISSN:00144886 ）

Activity-dependent changes in impulse conduction of single human motor axons: A stimulated single fiber electromyography study

Noto Y., Misawa S., Kanai K., Sato Y., Shibuya K., Isose S., Nasu S., Sekiguchi Y., Fujimaki Y., Ohmori S., Nakagawa M., Kuwabara S.

Clinical Neurophysiology   122 ( 12 )   2512 - 2517   2011.12（ ISSN:13882457 ）

Neuromuscular transmission is not impaired in axonal Guillain-Barré syndrome

Kuwabara S., Kokubun N., Misawa S., Kanai K., Isose S., Shibuya K., Noto Y., Mori M., Sekiguchi Y., Nasu S., Fujimaki Y., Hirata K., Yuki N.

Journal of Neurology, Neurosurgery and Psychiatry   82 ( 10 )   1174 - 1177   2011.10（ ISSN:00223050 ）

排尿障害教室　多系統萎縮症患者さんの尿路感染症の治療情報

金井 数明, 山本 達也

難病と在宅ケア   17 ( 5 )   49 - 52   2011.8（ ISSN:1880-9200 ）

Detection of bone lesions by CT in POEMS syndrome

Shibuya K., Misawa S., Horikoshi T., Kanai K., Isose S., Nasu S., Sekiguchi Y., Noto Y., Fujimaki Y., Nakaseko C., Kuwabara S.

Internal Medicine   50 ( 13 )   1393 - 1396   2011.7（ ISSN:09182918 ）

POEMS syndrome with Guillan-Barré syndrome-like acute onset: A case report and review of neurological progression in 30 cases

Isose S., Misawa S., Kanai K., Shibuya K., Sekiguchi Y., Nasu S., Fujimaki Y., Noto Y., Nakaseko C., Kuwabara S.

Journal of Neurology, Neurosurgery and Psychiatry   82 ( 6 )   678 - 680   2011.6（ ISSN:00223050 ）

Distal motor axonal dysfunction in amyotrophic lateral sclerosis

Noto Y., Kanai K., Misawa S., Shibuya K., Isose S., Nasu S., Sekiguchi Y., Fujimaki Y., Nakagawa M., Kuwabara S.

Journal of the Neurological Sciences   302 ( 1-2 )   58 - 62   2011.3（ ISSN:0022510X ）

Elevated CSF TDP-43 levels in amyotrophic lateral sclerosis: Specificity, sensitivity, and a possible prognostic value

Noto Y., Shibuya K., Sato Y., Kanai K., Misawa S., Sawai S., Mori M., Uchiyama T., Isose S., Nasu S., Sekiguchi Y., Fujimaki Y., Kasai T., Tokuda T., Nakagawa M., Kuwabara S.

Amyotrophic Lateral Sclerosis   12 ( 2 )   140 - 143   2011.3（ ISSN:17482968 ）

Sensorimotor manifestations without autonomic symptoms in two siblings with TTR Val107 familial amyloid polyneuropathy

Asahina M., Akaogi Y., Misawa S., Kanai K., Ando Y., Sakakibara R., Arai K., Hattori T., Kuwabara S.

Clinical Neurology and Neurosurgery   113 ( 2 )   139 - 141   2011.2（ ISSN:03038467 ）

Altered axonal excitability properties in juvenile muscular atrophy of distal upper extremity (Hirayama disease)

Sawai S., Misawa S., Kanai K., Isose S., Shibuya K., Noto Y., Fujimaki Y., Sekiguchi Y., Nasu S., Nomura F., Kuwabara S.

Clinical Neurophysiology   122 ( 1 )   205 - 209   2011.1（ ISSN:13882457 ）

Efficacy and safety of leuprorelin in patients with spinal and bulbar muscular atrophy (JASMITT study): A multicentre, randomised, double-blind, placebo-controlled trial

Katsuno M., Banno H., Suzuki K., Takeuchi Y., Kawashima M., Yabe I., Sasaki H., Aoki M., Morita M., Nakano I., Kanai K., Ito S., Ishikawa K., Mizusawa H., Yamamoto T., Tsuji S., Hasegawa K., Shimohata T., Nishizawa M., Miyajima H., Kanda F., Watanabe Y., Nakashima K., Tsujino A., Yamashita T., Uchino M., Fujimoto Y., Tanaka F., Sobue G.

The Lancet Neurology   9 ( 9 )   875 - 884   2010.9（ ISSN:14744422 ）

Mexiletine suppresses nodal persistent sodium currents in sensory axons of patients with neuropathic pain

Isose S., Misawa S., Sakurai K., Kanai K., Shibuya K., Sekiguchi Y., Nasu S., Noto Y., Fujimaki Y., Yokote K., Kuwabara S.

Clinical Neurophysiology   121 ( 5 )   719 - 724   2010.5（ ISSN:13882457 ）

Spectral analysis of heart rate variability in patients with Machado-Joseph disease

Asahina M., Katagiri A., Yamanaka Y., Akaogi Y., Fukushima T., Kanai K., Kuwabara S.

Autonomic Neuroscience: Basic and Clinical   154 ( 1-2 )   99 - 101   2010.4（ ISSN:15660702 ）

Multifocal conduction blocks in sarcoid peripheral neuropathy

Sawai S., Misawa S., Kobayashi M., Kanai K., Isose S., Shibuya K., Sekiguchi Y., Nasu S., Noto Y., Fujimaki Y., Koga S., Ohtani R., Kuwabara S.

Internal Medicine   49 ( 5 )   471 - 474   2010.3（ ISSN:09182918 ）

B cell aplasia and hypogammaglobulinemia after carbamazepine treatment

Yamamoto T., Uchiyama T., Takahashi H., Himuro K., Kanai K., Kuwabara S.

Internal Medicine   49 ( 7 )   707 - 708   2010.1（ ISSN:09182918 ）

Neuropathic pain is associated with increased nodal persistent Na ⁺ currents in human diabetic neuropathy

Misawa S., Sakurai K., Shibuya K., Isose S., Kanai K., Ogino J., Ishikawa K., Kuwabara S.

Journal of the Peripheral Nervous System   14 ( 4 )   279 - 284   2009.12（ ISSN:10859489 ）

Chronic inflammatory demyelinating polyneuropathy sera inhibit axonal growth of mouse dorsal root ganglion neurons by activation of Rho-kinase

Taniguchi J., Sawai S., Mori M., Kubo T., Kanai K., Misawa S., Isose S., Yamashita T., Kuwabara S.

Annals of Neurology   66 ( 5 )   694 - 697   2009.12（ ISSN:03645134 ）

Relapse of POEMS syndrome without increased level of VEGF

Kuwabara S., Kanai K., Misawa S., Nakaseko C.

Neuromuscular Disorders   19 ( 10 )   2009.10（ ISSN:09608966 ）

Physicochemical property changes of amino acid residues that accompany missense mutations in SCN1A affect epilepsy phenotype severity

Kanai K., Yoshida S., Hirose S., Oguni H., Kuwabara S., Sawai S., Hiraga A., Fukuma G., Iwasa H., Kojima T., Kaneko S.

Journal of Medical Genetics   46 ( 10 )   671 - 679   2009.10（ ISSN:00222593 ）

Utility of the distal compound muscle action potential duration for diagnosis of demyelinating neuropathies

Isose S., Kuwabara S., Kokubun N., Sato Y., Mori M., Shibuya K., Sekiguchi Y., Nasu S., Fujimaki Y., Noto Y., Sawai S., Kanai K., Hirata K., Misawa S.

Journal of the Peripheral Nervous System   14 ( 3 )   151 - 158   2009.9（ ISSN:10859489 ）

Preserved cardiac¹²³ I-MIBG uptake and lack of autonomic dysfunction in a PARK9 patient

Kanai K., Asahina M., Arai K., Tomiyama H., Kuwabara Y., Uchiyama T., Sekiguchi Y., Funayama M., Hattori N., Hattori T.

Movement Disorders   24 ( 9 )   1403 - 1405   2009.7（ ISSN:08853185 ）

【パーキンソン病　基礎・臨床研究のアップデート】 病因　関連遺伝子　ATP13A2(PARK9;Kufor-Rakeb症候群)

金井 数明

日本臨床   67 ( 増刊4 パーキンソン病 )   62 - 65   2009.6（ ISSN:0047-1852 ）

Differences in excitability properties of FDI and ADM motor axons

Jong S., Sawai S., Misawa S., Kanai K., Isose S., Kuwabara S.

Muscle and Nerve   39 ( 3 )   350 - 354   2009.3（ ISSN:0148639X ）

Motor nerve hyperexcitability and muscle cramps in Machado-Joseph disease

Kanai K., Kuwabara S.

Archives of Neurology   66 ( 1 )   2009.1（ ISSN:00039942 ）

Utility of trapezius EMG for diagnosis of amyotrophic lateral sclerosis

Sonoo M., Kuwabara S., Shimizu T., Komori T., Hirashima F., Inaba A., Hatanaka Y., Misawa S., Kugio Y., Ito E., Kanai K., Sawai S., Isose S., Kagamihara Y., Awatsu Y., Kondo S., Taguchi T., Ichikawa T., Yamada H., Sawada M., Uesugi H.

Muscle and Nerve   39 ( 1 )   63 - 70   2009.1（ ISSN:0148639X ）

Successful combination treatment with bevacizumab, thalidomide and autologous PBSC for severe POEMS syndrome

Ohwada C., Nakaseko C., Sakai S., Takeda Y., Abe D., Takeuchi M., Sakaida E., Masuda S., Shimizu N., Cho R., Nishimura M., Kanai K., Misawa S., Kuwabara S.

Bone Marrow Transplantation   43 ( 9 )   739 - 740   2009.1（ ISSN:02683369 ）

Neurologic improvement after peripheral blood stem cell transplantation in POEMS syndrome

Kuwabara S., Misawa S., Kanai K., Suzuki Y., Kikkawa Y., Sawai S., Hattori T., Nishimura M., Nakaseko C.

Neurology   71 ( 21 )   1691 - 1695   2008.11（ ISSN:00283878 ）

Development of individualized medicine for epilepsy based on genetic information

Kaneko S., Yoshida S., Kanai K., Yasui-Furukori N., Iwasa H.

Expert Review of Clinical Pharmacology   1 ( 5 )   661 - 681   2008.11（ ISSN:17512433 ）

Thalidomide reduces serum VEGF levels and improves peripheral neuropathy in POEMS syndrome

Kuwabara S., Misawa S., Kanai K., Sawai S., Hattori T., Nishimura M., Nakaseko C.

Journal of Neurology, Neurosurgery and Psychiatry   79 ( 11 )   1255 - 1257   2008.11（ ISSN:00223050 ）

Effects of age on excitability properties in human motor axons

Bae J., Sawai S., Misawa S., Kanai K., Isose S., Shibuya K., Kuwabara S.

Clinical Neurophysiology   119 ( 10 )   2282 - 2286   2008.10（ ISSN:13882457 ）

Changes in Na⁺ channel expression and nodal persistent Na ⁺ currents associated with peripheral nerve regeneration in mice

Nakata M., Baba H., Kanai K., Hoshi T., Sawai S., Hattori T., Kuwabara S.

Muscle and Nerve   37 ( 6 )   721 - 730   2008.6（ ISSN:0148639X ）

Changes in excitability properties associated with axonal regeneration in human neuropathy and mouse Wallerian degeneration

Sawai S., Kanai K., Nakata M., Hiraga A., Misawa S., Isose S., Hattori T., Kuwabara S.

Clinical Neurophysiology   119 ( 5 )   1097 - 1105   2008.5（ ISSN:13882457 ）

【ここまでわかったパーキンソン病研究】 基礎研究と遺伝性パーキンソン病の原因遺伝子　PARK9(Kufor-Rakeb症候群):ATP13A2　リソソーム蛋白質ATP13A2変異による常染色体劣性遺伝若年性パーキンソニズム

金井 数明

医学のあゆみ   225 ( 5 )   455 - 459   2008.5（ ISSN:0039-2359 ）

Genetically confirmed Huntington's disease masquerading as motor neuron disease

Kanai K., Kuwabara S., Sawai S., Nakata M., Misawa S., Isose S., Hirano S., Kawaguchi N., Katayama K., Hattori T.

Movement Disorders   23 ( 5 )   748 - 751   2008.4（ ISSN:08853185 ）

Dissociated small hand muscle atrophy in amyotrophic lateral sclerosis: Frequency, extent, and specificity

Kuwabara S., Sonoo M., Komori T., Shimizu T., Hirashima F., Inaba A., Misawa S., Hatanaka Y., Kanai K., Sawai S., Isose S., Hoshino S., Kagamihara Y., Kugio Y., Awatsu Y., Ichikawa T., Yamada H., Oishi C., Ito E., Kurono H., Kurokawa K., Sawada M.

Muscle and Nerve   37 ( 4 )   426 - 430   2008.4（ ISSN:0148639X ）

PARK9-linked parkinsonism in eastern asia: Mutation detection in ATP13A2 and clinical phenotype

Ning Y., Kanai K., Tomiyama H., Li Y., Funayama M., Yoshino H., Sato S., Asahina M., Kuwabara S., Takeda A., Hattori T., Mizuno Y., Hattori N.

Neurology   70 ( 16 PART 2 )   1491 - 1493   2008.1（ ISSN:00283878 ）

Altered axonal ion channel function in amyotrophic lateral sclerosis

Kuwabara S., Kanai K.

Brain and Nerve   59 ( 10 )   1109 - 1115   2007.10（ ISSN:00068969 ）

【ALS-研究と診療の進歩】 ALSの軸索イオンチャネル障害

桑原 聡, 金井 数明

BRAIN and NERVE: 神経研究の進歩   59 ( 10 )   1109 - 1115   2007.10（ ISSN:1881-6096 ）

Anti-GQ1b antibody does not affect neuromuscular transmission in human limb muscle

Kuwabara S., Misawa S., Takahashi H., Sawai S., Kanai K., Nakata M., Mori M., Hattori T., Yuki N.

Journal of Neuroimmunology   189 ( 1-2 )   158 - 162   2007.9（ ISSN:01655728 ）

Time course of axonal regeneration in acute motor axonal neuropathy

Tamura N., Kuwabara S., Misawa S., Kanai K., Nakata M., Sawai S., Mori M., Hattori T.

Muscle and Nerve   35 ( 6 )   793 - 795   2007.6（ ISSN:0148639X ）

Median-radial sensory nerve comparative studies in the detection of median neuropathy at the wrist in diabetic patients

Imada M., Misawa S., Sawai S., Tamura N., Kanai K., Sakurai K., Sakamoto S., Nomura F., Hattori T., Kuwabara S.

Clinical Neurophysiology   118 ( 6 )   1405 - 1409   2007.6（ ISSN:13882457 ）

Is excitation-contraction coupling impaired in myasthenia gravis?

Nakata M., Kuwabara S., Kawaguchi N., Takahashi H., Misawa S., Kanai K., Tamura N., Sawai S., Motomura M., Shiraishi H., Takamori M., Maruta T., Yoshikawa H., Hattori T.

Clinical Neurophysiology   118 ( 5 )   1144 - 1148   2007.5（ ISSN:13882457 ）

Gangliosides contribute to stability of paranodal junctions and ion channel clusters in myelinated nerve fibers

Susuki K., Baba H., Tohyama K., Kanai K., Kuwabara S., Hirata K., Furukawa K., Furukawa K., Rasband M., Yuki N.

GLIA   55 ( 7 )   746 - 757   2007.5（ ISSN:08941491 ）

Paroxysmal kinesigenic choreoathetosis (PKC): Confirmation of linkage to 16p11-q21, but unsuccessful detection of mutations among 157 genes at the PKC-critical region in seven PKC families

Kikuchi T., Nomura M., Tomita H., Harada N., Kanai K., Konishi T., Yasuda A., Matsuura M., Kato N., Yoshiura K., Niikawa N.

Journal of Human Genetics   52 ( 4 )   334 - 341   2007.4（ ISSN:14345161 ）

Failure of treatment with anti-VEGF monoclonal antibody for long-standing POEMS syndrome

Kanai K., Kuwabara S., Misawa S., Hattori T.

Internal Medicine   46 ( 6 )   311 - 313   2007.3（ ISSN:09182918 ）

Sporadic case of spinocerebellar ataxia type 17: Treatment observations for managing urinary and psychotic symptoms [8]

Kanai K., Sakakibara R., Uchiyama T., Liu Z., Yamamoto T., Ito T., Hirano S., Asahina M., Kuwabara S., Hattori T., Fukami G., Arai K., Yamaguchi C., Nomura F.

Movement Disorders   22 ( 3 )   441 - 443   2007.2（ ISSN:08853185 ）

The effects of physiological fluctuation of serum potassium levels on excitability properties in healthy human motor axons

Kuwabara S., Misawa S., Kanai K., Tamura N., Nakata M., Sawai S., Hattori T.

Clinical Neurophysiology   118 ( 2 )   278 - 282   2007.2（ ISSN:13882457 ）

Acute motor axonal neuropathy presenting with bowel, bladder, and erectile dysfunction [1]

Sawai S., Sakakibara R., Uchiyama T., Liu Z., Yamamoto T., Ito T., Kuwabara S., Kanai K., Asahina M., Yamanaka T., Odaka T., Yamaguchi T., Hattori T.

Journal of Neurology   254 ( 2 )   250 - 252   2007.2（ ISSN:03405354 ）

Isolated vomiting due to a unilateral dorsal vagal complex lesion [5]

Sawai S., Sakakibara R., Kanai K., Kawaguchi N., Uchiyama T., Yamamoto T., Ito T., Liu Z., Hattori T.

European Neurology   56 ( 4 )   246 - 248   2006.12（ ISSN:00143022 ）

Increased nodal persistent Na+ currents in human neuropathy and motor neuron disease estimated by latent addition

Tamura N., Kuwabara S., Misawa S., Kanai K., Nakata M., Sawai S., Hattori T.

Clinical Neurophysiology   117 ( 11 )   2451 - 2458   2006.11（ ISSN:13882457 ）

Rho-kinase inhibition enhances axonal regeneration after peripheral nerve injury

Hiraga A., Kuwabara S., Doya H., Kanai K., Fujitani M., Taniguchi J., Arai K., Mori M., Hattori T., Yamashita T.

Journal of the Peripheral Nervous System   11 ( 3 )   217 - 224   2006.9（ ISSN:10859489 ）

Distal excitability changes in motor axons in amyotrophic lateral sclerosis

Nakata M., Kuwabara S., Kanai K., Misawa S., Tamura N., Sawai S., Hattori T., Bostock H.

Clinical Neurophysiology   117 ( 7 )   1444 - 1448   2006.7（ ISSN:13882457 ）

Voltage-gated potassium channel antibody-associated encephalitis with basal ganglia lesions

Hiraga A., Kuwabara S., Hayakawa S., Ito S., Arimura K., Kanai K., Yonezu T., Hattori T.

Neurology   66 ( 11 )   1780 - 1781   2006.6（ ISSN:00283878 ）

Leucocytoclastic vasculitic neuropathy diagnosed by biopsy of normal appearing skin

Yamanaka Y., Hiraga A., Arai K., Mori M., Kanai K., Hattori T., Kuwabara S., Oide T., Tanizawa T.

Journal of Neurology, Neurosurgery and Psychiatry   77 ( 5 )   706 - 707   2006.5（ ISSN:00223050 ）

Aldose reductase inhibition alters nodal Na+ currents and nerve conduction in human diabetics

Misawa S., Kuwabara S., Kanai K., Tamura N., Nakata M., Sawai S., Yagui K., Hattori T.

Neurology   66 ( 10 )   1545 - 1549   2006.5（ ISSN:00283878 ）

Latent addition in human motor and sensory axons: Different site-dependent changes across the carpal tunnel related to persistent Na+ currents

Kuwabara S., Misawa S., Tamura N., Nakata M., Kanai K., Sawai S., Ogawara K., Hattori T.

Clinical Neurophysiology   117 ( 4 )   810 - 814   2006.4（ ISSN:13882457 ）

Altered axonal excitability properties in amyotrophic lateral sclerosis: Impaired potassium channel function related to disease stage

Kanai K., Kuwabara S., Misawa S., Tamura N., Ogawara K., Nakata M., Sawai S., Hattori T., Bostock H.

Brain   129 ( 4 )   953 - 962   2006.4（ ISSN:00068950 ）

Nodal persistent Na+ currents in human diabetic nerves estimated by the technique of latent addition

Misawa S., Kuwabara S., Kanai K., Tamura N., Nakata M., Ogawara K., Yagui K., Hattori T.

Clinical Neurophysiology   117 ( 4 )   815 - 820   2006.4（ ISSN:13882457 ）

Autologous peripheral blood stem cell transplantation for POEMS syndrome

Kuwabara S., Misawa S., Kanai K., Kikkawa Y., Nishimura M., Nakaseko C., Cho R., Hattori T.

Neurology   66 ( 1 )   105 - 107   2006.1（ ISSN:00283878 ）

Meningitis-retention syndrome: An unrecognized clinical condition

Sakakibara R., Uchiyama T., Liu Z., Yamamoto T., Ito T., Uzawa A., Suenaga T., Kanai K., Awa Y., Sugiyama Y., Hattori T.

Journal of Neurology   252 ( 12 )   1495 - 1499   2005.12（ ISSN:03405354 ）

【精神神経疾患とゲノム　最近の動向】　てんかんの分子遺伝学研究のUp to date

兼子 直, 金井 数明, 福間 五龍, 岡田 元宏, 桑原 聡, 廣瀬 伸一

ゲノム医学   5 ( 3 )   241 - 245   2005.6（ ISSN:1346-4671 ）

基礎研究の新たな方向性を解く　疾患解明　てんかん　責任遺伝子解明の進展とその後の課題

兼子 直, 金井 数明, 岡田 元宏, 桑原 聡, 廣瀬 伸一

実験医学   23 ( 5 )   776 - 781   2005.3（ ISSN:0288-5514 ）

The effects of mexiletine on excitability properties of human median motor axons

Kuwabara S., Misawa S., Tamura N., Kanai K., Hiraga A., Ogawara K., Nakata M., Hattori T.

Clinical Neurophysiology   116 ( 2 )   284 - 289   2005.2（ ISSN:13882457 ）

Axonal potassium conductance and glycemic control in human diabetic nerves

Misawa S., Kuwabara S., Kanai K., Tamura N., Hiraga A., Nakata M., Ogawara K., Hattori T.

Clinical Neurophysiology   116 ( 5 )   1181 - 1187   2005.1（ ISSN:13882457 ）

てんかんの分子生物学　てんかんの遺伝子

兼子 直, 金井 数明, 朱 剛, 黄 欽威, 岡田 元宏

神経研究の進歩   48 ( 6 )   889 - 898   2004.12（ ISSN:0001-8724 ）

The acute effects of glycemic control on axonal excitability in human diabetics

Kitano Y., Kuwabara S., Misawa S., Ogawara K., Kanai K., Kikkawa Y., Yagui K., Hattori T.

Annals of Neurology   56 ( 4 )   462 - 467   2004.10（ ISSN:03645134 ）

Effect of localization of missense mutations in SCN1A on epilepsy phenotype severity

Kanai K., Hirose S., Oguni H., Fukuma G., Shirasaka Y., Miyajima T., Wada K., Iwasa H., Yasumoto S., Matsuo M., Ito M., Mitsudome A., Kaneko S.

Neurology   63 ( 2 )   329 - 334   2004.7（ ISSN:00283878 ）

てんかんの遺伝子診断の可能性

兼子 直, 金井 数明

精神神経学雑誌   106 ( 5 )   660 - 670   2004.5（ ISSN:0033-2658 ）

Threshold electrotonus in chronic inflammatory demyelinating polyneuropathy: Correlation with clinical profiles

Sung J., Kuwabara S., Kaji R., Ogawara K., Mori M., Kanai K., Nodera H., Hattori T., Bostock H.

Muscle and Nerve   29 ( 1 )   28 - 37   2004.1（ ISSN:0148639X ）

The refractory period of transmission is impaired in axonal Guillain-Barré syndrome

Kuwabara S., Bostock H., Ogawara K., Sung J., Kanai K., Mori M., Hattori T., Burke D.

Muscle and Nerve   28 ( 6 )   683 - 689   2003.12（ ISSN:0148639X ）

神経疾患とチャネロパチー　チャネロパチーとしてのてんかん

兼子 直, 金井 数明

神経治療学   20 ( 6 )   707 - 714   2003.11（ ISSN:0916-8443 ）

【チャネル・トランスポーターの分子医学2003】　てんかんとイオンチャネル・トランスポーター

金井 数明, 兼子 直

Molecular Medicine   40 ( 7 )   792 - 800   2003.6（ ISSN:0918-6557 ）

Muscle cramp in Machado-Joseph disease - Altered motor axonal excitability properties and mexiletine treatment

Kanai K., Kuwabara S., Arai K., Sung J., Ogawara K., Hattori T.

Brain   126 ( 4 )   965 - 973   2003.4（ ISSN:00068950 ）

【精神疾患の分子医学　ここまで進んだ病因の解明】　てんかんの分子遺伝学

兼子 直, 岡田 元宏, 和田 一丸, 金井 数明

Molecular Medicine   40 ( 3 )   296 - 306   2003.2（ ISSN:0918-6557 ）

【てんかん】　てんかん症候群の遺伝子

兼子 直, 金井 数明, 和田 一丸

神経内科   58 ( 2 )   111 - 115   2003.2（ ISSN:0386-9709 ）

Leukocytoclastic-vasculitic neuropathy associated with chronic Epstein-Barr virus infection

Kanai K., Kuwabara S., Mori M., Arai K., Yamamoto T., Hattori T.

Muscle and Nerve   27 ( 1 )   113 - 116   2003.1（ ISSN:0148639X ）

Exocytosis mechanism as a new targeting site for mechanisms of action of antiepileptic drugs

Okada M., Zhu G., Yoshida S., Kanai K., Hirose S., Kaneko S.

Life Sciences   72 ( 4-5 )   465 - 473   2002.12（ ISSN:00243205 ）

Axonal hyperpolarization associated with acute hypokalemia: Multiple excitability measurements as indicators of the membrane potential of human axons

Kuwabara S., Kanai K., Sung J., Ogawara K., Hattori T., Burke D., Bostock H.

Muscle and Nerve   26 ( 2 )   283 - 287   2002.8（ ISSN:0148639X ）

Patterns of nerve conduction abnormalities in poems syndrome

Sung J., Kuwabara S., Ogawara K., Kanai K., Hattori T.

Muscle and Nerve   26 ( 2 )   189 - 193   2002.8（ ISSN:0148639X ）

Differences in membrane properties of axonal and demyelinating Guillain-Barré syndromes

Kuwabara S., Ogawara K., Sung J., Mori M., Kanai K., Hattori T., Yuki N., Lin C., Burke D., Bostock H.

Annals of Neurology   52 ( 2 )   180 - 187   2002.8（ ISSN:03645134 ）