Organization
School of Medicine (Life Sciences and Social Medicine) Department of Cellular and Integrative Physiology Assistant Professor
Title
Assistant Professor
YOSHIE Susumu
Degree
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医学博士 ( 2013.3 信州大学 )
Research Interests
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イオンチャネル、トランスポーター、CFTR、iPS細胞、分化、気道、再生
Research Areas
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Life Science / Clinical pharmacy / General Physiology
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Life Science / Physiology / General Physiology
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Life Science / Developmental biology / Developmental Biology
Education
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Shinshu University Graduate School, Division of Medical Sciences
- 2013.3
Country： Japan
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Shinshu University Graduate School, Division of Medical Sciences
- 2009.3
Country： Japan
Research History
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福島県立医科大学 医学部 細胞統合生理学講座 助教
2015.10 - Now
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福島県立医科大学 医学部 耳鼻咽喉科学講座 研究員
2013.10 - 2015.9
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自治医科大学 分子病態治療研究センター 研究員
2013.4 - 2013.9
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日本学術振興会特別研究員(DC2)
2011.4 - 2013.3
Papers
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Approach for Elucidating the Molecular Mechanism of Epithelial to Mesenchymal Transition in Fibrosis of Asthmatic Airway Remodeling Focusing on Cl- Channels
Yoshie S, Murono S, Hazama A
International Journal of Molecular Sciences 25 ( 1 ) 289 2023.12
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Dysfunction of Cl - channels promotes epithelial to mesenchymal transition in oral squamous cell carcinoma via activation of Wnt/β-catenin signaling pathway
Kakinouchi K, Yoshie S, Tsuji S, Murono S, Hazama A
Biochemical and Biophysical Research Communications 555 95 - 101 2021.4
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Negative chronotropic and inotropic effects of lubiprostone on iPS cell-derived cardiomyocytes via activation of CFTR
Akita H, Yoshie S, Ishida T, Takeishi Y, Hazama A
BMC Complementary Medicine and Therapies 20 ( 1 ) 118 - 127 2020.4
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Cl- channels regulate lipid droplet formation via Rab8a expression during adipocyte differentiation.
Ouchi K, Yoshie S, Miyake M, Hazama A
Bioscience, biotechnology, and biochemistry 84 ( 2 ) 247 - 255 2020.2（ ISSN:0916-8451 ）
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Yoshie S, Omori K, Hazama A
Channels (Austin, Tex.) 13 ( 1 ) 227 - 234 2019.12（ ISSN:1933-6950 ）
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Yoshie S, Nakamura R, Kobayashi D, Miyake M, Omori K, Hazama A
Journal of cellular physiology 234 ( 9 ) 15951 - 15962 2019.2（ ISSN:0021-9541 ）
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Cytotoxicity and Antiproliferative Activity of Indonesian Red Algae Acanthophora muscoides Crude Ethanol Extracts
Sunarpi H, Prasedya SE, Ariyana M, Nikmatullah A, Zulkifli L, Yoshie S, Miyake M, Kobayashi D, Hazama A
Journal of Biological Sciences 18 ( 8 ) 425 - 433 2018.12
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Evaluation of Indonesian selected macroalgae for their antitumor and cytoprotective activity
Prasedya E., Ariyana M., Hamdin C., Nikmatullah A., Yoshie S., Miyake M., Kobayashi D., Hazama A., Sunarpi H.
Journal of Applied Pharmaceutical Science 8 ( 11 ) 123 - 130 2018.11
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Implantation of Induced Pluripotent Stem Cell-Derived Tracheal Epithelial Cells.
Masakazu Ikeda, Mitsuyoshi Imaizumi, Susumu Yoshie, Ryosuke Nakamura, Koshi Otsuki, Shigeru Murono, Koichi Omori
Annals of Otology, Rhinology & Laryngology 126 ( 7 ) 517 - 524 2017.7
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Heparin cross-linked collagen sponge scaffolds improve functional regeneration of rat tracheal epithelium.
Ryosuke Nakamura, Akiko Tani, Susumu Yoshie, Masakazu Ikeda, Ikuo Wada, Akihiro Hazama, Yukio Nomoto, Yasuhiro Tada, Tatsuo Nakamura, Koichi Omori.
Journal of Tissue Engineering and Regenerative Medicine. 2017.1
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Generation of airway epithelial cells with natitve characteristics from mouse induced pluripotent stem cells.
Susumu Yoshie, Mitsuyoshi Imaizumi, Ryosuke Nakamura, Masakazu Ikeda, Koshi Otsuki, Yukio Nomoto, Ikuo Wada, Koichi Omori.
Cell and Tissue Research 364 ( 2 ) 319 - 330 2016.5
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Regeneration of tracheal epithelium using mouse induced pluripotent stem cells.
Masakazu Ikeda, Mitsuyoshi Imaizumi, Susumu Yoshie, Koshi Otsuki, Masao Miyake, Akihiro Hazama, Ikuo Wada, Koichi Omori.
Acta Oto-laryngologica 136 ( 4 ) 373 - 378 2016.4
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Potential of laryngeal muscle regeneration using induced pluripotent stem cell-derived skeletal muscle cells.
Dirja Bayu Tirta, Susumu Yoshie, Masakazu Ikeda, Mitsuyoshi Imaizumi, Ryosuke Nakamura, Koshi Otsuki, Yukio Nomoto, Ikuo Wada, Akihiro Hazama, Koichi Omori.
Acta Oto-laryngologica 136 ( 4 ) 391 - 396 2016.4
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Visualization of mouse induced pluripotent stem cells for evaluation of tracheal regeneration
Yoshie S., Ikeda M., Imaizumi M., Otsuki K., Nomoto Y., Wada I., Omori K.
Acta Oto-Laryngologica 135 ( 4 ) 395 - 401 2015.4（ ISSN:00016489 ）
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FGF7 and cell density are required for differentiation of pancreatic amylase-positive cells from human ES cells.
Sakiko Takizawa-Shirasawa, Susumu Yoshie, Fengming Yue, Akimi Mogi, Tadayuki Yokoyama, Daihachiro Tomotsune, Katsunori Sasaki.
Cell and Tissue Research 354 ( 3 ) 751 - 759 2013.12
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Gene pathway analysis of the mechanism by which the Rho-associated kinase inhibitor Y-27632 inhibits apoptosis in isolated thawed human embryonic stem cells.
Hinako Ichikawa, Naohiro Nakata, Youichi Abo, Sakiko Shirasawa, Tadayuki Yokoyama, Susumu Yoshie, Fengming Yue, Daihachiro Tomotsune, Katsunori Sasaki.
Cryobiology 64 ( 1 ) 12 - 22 2012.2
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Establishment of novel detection system for embryonic stem cell-derived hepatocyte-like cells based on nongenetic manipulation with indocyanine green.
Susumu Yoshie, Jun Ito, Sakiko Shirasawa, Tadayuki Yokoyama, Yuu Fujimura, Kazuo Takeda, Masahiro Mizuguchi, Ken Matsumoto, Daihachiro Tomotsune, Katsunori Sasaki.
Tissue Engineering Part C 18 ( 1 ) 12 - 20 2012.1
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In vitro transdifferentiation of HepG2 cells to Pancreatic-like cells by CCl4, D-Galactosamine, and ZnCl2.
Yoshiya Kanoh, Daihachiro Tomotsune, Sakiko Shirasawa, Susumu Yoshie, Hinako Ichikawa, Tadayuki Yokoyama, Shinichi Mae, Jun Ito, Masahiro Mizuguchi, Ken Matsumoto, Fengming Yue, Katsunori Sasaki.
Pancreas 40 ( 8 ) 1245 - 1252 2011.11
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Freeze-thawing single human embryonic stem cells induce E-cadherin and actin filament network disruption via G13 signaling.
Hinako Ichikawa, Susumu Yoshie, Naohiro Nakata, Youichi Abo, Sakiko Shirasawa, Tadayuki Yokoyama, Fengming Yue, Katsunori Sasaki.
Cryo Letters 32 ( 6 ) 516 - 524 2011.11
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Pancreatic exocrine enzyme-producing cell differentiation via embryoid bodies from human embryonic stem cells.
Sakiko Shirasawa, Susumu Yoshie, Fengming Yue, Hinako Ichikawa, Tadayuki Yokoyama, Mika Nagai, Daihachiro Tomotsune, Katsunori Sasaki.
Biochemical and Biophysical Research Communications 410 ( 3 ) 608 - 613 2011.7
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A novel stepwise differentiation of functional pancreatic exocrine cells from embryonic stem cells.
Sakiko Shirasawa, Susumu Yoshie, Tadayuki Yokoyama, Daihachiro Tomotsune, Fengming Yue, Katsunori Sasaki.
Stem Cells and Development 20 ( 6 ) 1071 - 1078 2011.6
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Combination of small molecules enhances differentiation of mouse embryonic stem cells into intermediate mesoderm through BMP7-positive cells.
Shinichi Mae, Sakiko Shirasawa, Susumu Yoshie, Fumi Sato, Yoshiya Kanoh, Hinako Ichikawa, Tadayuki Yokoyama, Fengming Yue, Daihachiro Tomotsune, Katsunori Sasaki.
Biochemical and Biophysical Research Communications 393 ( 4 ) 877 - 882 2010.3
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Lanford medium induces high quality hepatic lineage cell differentiation directly from mouse embryonic stem cell-derived mesendoderm.
Susumu Yoshie, Sakiko Shirasawa, Tadayuki Yokoyama, Yoshiya Kanoh, Shunsuke Takei, Masahiro Mizuguchi, Ken Matsumoto, Daihachiro Tomotsune, Katsunori Sasaki.
Biochemical and Biophysical Research Communications 391 ( 3 ) 1477 - 1482 2010.1
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Hepatocyte differentiation from human ES cells using the simple embryoid body formation method and the staged-additional cocktail.
Katsunori Sasaki, Hinako Ichikawa, Shunsuke Takei, Heesung No, Daihachiro Tomotsune, Yoshiya Kano, Tadayuki Yokoyama, Sakiko Shirasawa, Akimi Mogi, Susumu Yoshie, Shujiro Sakaki, Satoshi Yamada, Ken Matsumoto, Masahiro Mizuguchi, Fengming Yue, Yoshiki Tanaka.
TheScientificWorldJournal 1 ( 9 ) 884 - 890 2009.9
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Bone morphogenetic protein-4 promotes induction of cardiomyocytes from human embryonic stem cells in serum-based embryoid body development.
Shunsuke Takei, Hinako Ichikawa, Kohei Johkura, Akimi Mogi, Heesung No, Susumu Yoshie, Daihachiro Tomotsune, Katsunori Sasaki.
Am J Physiol Heart Circ Physiol 296 ( 6 ) 1793 - 1803 2009.6
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Localization of Liv2 as an immature hepatocyte marker in EB outgrowth.
Ikkei Takashimizu, Yoshiki Tanaka, Susumu Yoshie, Yoshiya Kanoh, Hinako Ichikawa, Naoko Ogiwara, Kohei Johkura, Katsunori Sasaki.
TheScientificWorldJournal 1 ( 9 ) 190 - 199 2009.3
Books
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Recent Advances in iPSC-Derived Cell Types
Alexander Birbrair（Application of iPS cell-derived airway epithelial cells for cell-based therapy and disease models）
ELSEVIER 2021.1
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Regenerative Medicine and Tissue Engineering.
（Induce differentiation of ESCs by coculture system.）
2013 （ ISBN:978-953-51-1108-5 ）
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Advances in Regenerative Medicine.
（A strategy using pluripotent stem cell-derived hepatocytes for stem cell-based therapies.）
2011 （ ISBN:978-953-307-732-1 ）
Industrial property rights
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特定の細胞内に選択的に取り込まれる蛍光色素を利用して多種類の細胞から特定の細胞を純化濃縮する方法
Research Projects
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気道上皮膜輸送体とiPS細胞から明らかにする喘息気道における杯細胞化生の病態解明
2022.4 - 2025.3
吉江 進
科学研究費補助金 基盤研究(C)
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ヒトiPS細胞とたばこ煙を利用した杯細胞過形成機構の解明に関する研究
2021.4 - 2024.3
公益財団法人喫煙科学研究財団 若手研究助成
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iPS細胞を利用した気道リモデリングに伴う杯細胞過形成機構の解明
2017.10 - 2020.10
公益財団法人武田科学振興財団 医学系研究奨励金
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iPS細胞とたばこ煙を利用した杯細胞過形成機構の解明に関する研究
2017.4 - 2020.3
公益財団法人喫煙科学研究財団 若手研究助成金
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iPS細胞を利用した杯細胞過形成機構の解明に関する研究
2017.4 - 2020.3
科学研究費補助金 若手研究(B)
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ヒトiPS細胞を利用した次世代型気管再生技術の開発
2016.3 - 2017.3
公益財団法人上原記念生命科学財団 研究奨励金
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マウスおよびヒトiPS細胞を用いた頭頸部組織の再生技術開発
2015.4 - 2017.3
大森孝一、今泉光雅、吉江 進
科学研究費補助金 基盤研究(B)
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ヒトiPS細胞由来気管軟骨細胞とIn situ Tissue Engineeringを組み合わせた小児気管再生の基盤技術開発に関する研究
2014.12 - 2015.11
公益財団法人母子健康協会 小児医学研究助成金
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ヒトiPS細胞を用いた気管軟骨への分化誘導に関する研究
2014.4 - 2017.3
科学研究費補助金 若手研究(B)
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ES細胞、iPS細胞を用いた時空間的制御による肝細胞分化誘導に関する研究
2011.4 - 2013.3
科学研究費補助金 特別研究員奨励費