医療－産業トランスレーショナルリサーチセンター 平成24年（2012年）
論文
〔原著〕
YOSHIHARA, H; FUKUSHIMA, T; HAKUNO, F; SAEKI, Y; TANAKA, K; ITO, A; YOSHIDA, M; IEMURA, S*; NATSUME, T; ASANO, T; CHIDA, K; GIRNITA, L; TAKAHASHI, S. Insulin/insulin-like growth factor (IGF) stimulation abrogates an association between a deubiquitinating enzyme USP7 and insulin receptor substrates (IRSs) followed by proteasomal degradation of IRSs. Biochemical and Biophysical Research Communications. 2012 06; 423(1):122-127.
OKATSU, K; IEMURA, SI*; KOYANO, F; GO, E; KIMURA, M; NATSUME, T; TANAKA, K; MATSUDA, N. Mitochondrial hexokinase HKI is a novel substrate of the Parkin ubiquitin ligase. Biochemical and Biophysical Research Communications. 2012 10; 428(1): 197-202.
KOBAYASHI, H; HARADA, H; NAKAMURA, M; FUTAMURA, Y; ITO, A; YOSHIDA, M; IEMURA, SI*; SHIN-YA, K; DOI, T; TAKAHASHI, T; NATSUME, T; IMOTO, M; SAKAKIBARA, Y. Comprehensive predictions of target proteins based on protein-chemical interaction using virtual screening and experimental verifications. BMC Chemical Biology. 2012 04; 12: 2.
OHNUKI, S; KOBAYASHI, T; OGAWA, H; KOZONE, I; UEDA, JY; TAKAGI, M*; SHIN-YA, K; HIRATA, D; NOGAMI, S; OHYA, Y. Analysis of the biological activity of a novel 24-membered macrolide JBIR-19 in Saccharomyces cerevisiae by the morphological imaging program CalMorph. FEMS Yeast Research. 2012; 12:293-304.
TANI, H; MIZUTANI, R; SALAM, KA; TANO, K; IJIRI, K; WAKAMATSU, A; ISOGAI, T*; SUZUKI, Y; AKIMITSU, N. Genome-wide determination of RNA stability reveals hundreds of short-lived non-coding transcripts in mammals. Genome Research. 2012 05; 22(5):947-956.
IZUMIKAWA, M; HOSOYA, T; TAKAGI, M*; SHIN-YA, K. A new cyclizidine analog-JBIR-102-from Saccharopolyspora sp. RL78 isolated from mangrove soil. Journal of Antibiotics. 2012; 65:41-43.
KAWAHARA, T; TAKAGI, M*; SHIN-YA, K. JBIR-124: a novel antioxidative agent from a marine sponge-derived fungus Penicillium citrinum SpI080624G1f01. Journal of Antibiotics. 2012; 65:45-47.
KAWAHARA, T; TAKAGI, M*; SHIN-YA, K. Three new depsipeptides, JBIR-113, JBIR-114 and JBIR-115, isolated from a marine sponge-derived Penicillium sp. fS36. Journal of Antibiotics. 2012; 65:147-150.
OHTE, S; KOKABU, S; IEMURA, S*; SASANUMA, H; YONEYAMA, K; SHIN, M; SUZUKI, S; FUKUDA, T; NAKAMURA, Y; JIMI, E; NATSUME, T; KATAGIRI, T. Identification and functional analysis of Zranb2 as a novel Smad-binding protein that suppresses BMP signaling. Journal of Cellular Biochemistry. 2012 03; 113(3):808-814.
KAWAHARA, T; IZUMIKAWA, M; OTOGURO, M; YAMAMURA, H; HAYAKAWA, M; TAKAGI, M*; SHIN-YA, K. JBIR-94 and JBIR-125, Antioxidative Phenolic Compounds from Streptomyces sp. R56-07. Journal of Natural Products. 2012; 75:107-110.
IZUMIKAWA, M; TAKAGI, M*; SHIN-YA,K. JBIR-78 and JBIR-95: Phenylacetylated peptides isolated from Kibdelosporangium sp. AK-AA56. Journal of Natural Products. 2012; 75:280-284.
HOSOYA, T; HIROKAWA, T; TAKAGI, M*; SHIN-YA, K. Trichostatin Analogues JBIR-109, JBIR-110, and JBIR-111 from the marine sponge-derived Streptomyces sp. RM72. Journal of Natural Products. 2012; 75:285-289.
TAKAGI, M*; UEDA, JY; HWANG, JH; HASHIMOTO, J; IZUMIKAWA, M; MURAKAMI, H; SEKIDO, Y; SHIN-YA, K. Tyrosyl-DNA Phosphodiesterase 1 Inhibitor from an Anamorphic Fungus. Journal of Natural Products. 2012; 75:764-767.
KHAN, ST; TAKAGI, M*; SHIN-YA, K. Actinobacteria Associated with the Marine Sponges Cinachyra sp., Petrosia sp., and Ulosa sp. and Their Culturability. Microbes and Environments. 2012; 27:99-104.
FUJIMOTO, M; TAKAKI, E; TAKII, R; TAN, K; PRAKASAM, R; HAYASHIDA, N; IEMURA, S*; NATSUME, T; NAKAI, A. RPA Assists HSF1 Access to Nucleosomal DNA by Recruiting Histone Chaperone FACT. Molecular Cell. 2012 10; 48(2):182-194.
SEKINE, Y; HATANAKA, R; WATANABE, T; SONO, N; IEMURA, SI*; NATSUME, T; KURANAGA, E; MIURA, M; TAKEDA, K; ICHIJO, H. The Kelch Repeat Protein KLHDC10 Regulates Oxidative Stress-Induced ASK1 Activation by Suppressing PP5. Molecular Cell. 2012 10; 48(5): 692-704.
MARUYAMA, C; TOYODA, J; KATO, Y; IZUMIKAWA, M; TAKAGI, M*; SHIN-YA, K; KATANO, H; UTAGAWA, T; HAMANO, Y. A stand-alone adenylation domain forms amide bonds in streptothricin biosynthesis. Nature Chemical Biology. 2012 09; 8(9):791-797.
MARUYAMA, Yukio; KAWAMURA, Yoshifumi; NISHIKAWA, Tetsuo; ISOGAI, Takao*; NOMURA, Nobuo; GOSHIMA, Naoki*. HGPD: Human Gene and Protein Database, 2012 update. Nucleic Acids Research. 2012; 40:D924-D929.
MIZUTANI, Rena; WAKAMATSU, Ai; TANAKA, Noriyuki; YOSHIDA, Hiroshi; TOCHIGI, Naobumi; SUZUKI, Yoshio; OONISHI, Tadahiro; TANI, Hidenori; TANO, Keiko; IJIRI, Kenichi; ISOGAI, Takao*; AKIMITSU, Nobuyoshi. Identification and Characterization of Novel Genotoxic Stress-inducible Nuclear Long Noncoding RNAs in Mammalian Cells. PLoS ONE. 2012 04; 7(4):e34949.
NISHINA, T; KOMAZAWA-SAKON, S; YANAKA, S; PIAO, X; ZHENG, DM; PIAO, JH; KOJIMA, Y; YAMASHINA, S; SANO, E; PUTOCZKI, T; DOI, T; UENO, T; EZAKI, J*; USHIO, H; ERNST, M; TSUMOTO, K; OKUMURA, K; NAKANO, H. Interleukin-11 links oxidative stress and compensatory proliferation. Science Signaling. 2012 01; 5(207):ra5.
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〔症例報告〕
HAKOZAKI, Michiyuki*; TAJINO, Takahiro*; WATANABE, Kazuo; YAMADA, Hitoshi*; KIKUCHI, Shinichi*; HOJO, Hiroshi*; ISHIDA, Tsuyoshi; KONNO, Shinichi*. Intraosseous spindle cell hemangioma of the calcaneus: a case report and review of the literature. Annals of Diagnostic Pathology. 2012 10; 16(5):369-373.
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〔その他〕
箱﨑道之*, 小池日登美, 佐久間貞典, 大久保雅通. 糖尿病外来における運動指導. 糖尿病診療マスター. 2012 11; 10(7):568-578.
箱﨑道之*, 紺野愼一*. A prospective randomized double-blinded pilot study to examine the effect of botulinum toxin type A injection versus Lidocaine/Depomedrol injection on residual and phantom limb pain: initial report（文献抄訳）. ペインクリニック. 2012 10; 33(10):1465.
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著書・訳書
IEMURA, S*; NATSUME, T. One-by-One Sample Preparation Method for Protein Network Analysis. In: CAI, J ed. Protein Interaction. Croatia: Intech; 2012 03. p.293-310.
ISOGAI, Takao*; WAKAMATSU, Ai. mRNA diversity of genes by alternative splicing during neuronal differentiation of NT2 pluripotential human embryonal carcinoma cells by all-trans retinoic acid. In: CHENG, Li-Hong ; ITO, Yuto ed. Retinoic Acid: Structure, Mechanisms and Roles in Disease. Hauppauge, NY, USA: Nova Science Publisher; 2012 04. p.53-86.
矢吹省司*, 田地野崇宏*, 箱﨑道之*. 砂時計腫の分類. In: 紺野愼一* 編集. 運動器の計測線・計測値ハンドブック. 東京: 南江堂; 2012 11. p.500-502.
山田 仁*, 箱﨑道之*. 脊髄動静脈奇形. In: 紺野愼一* 編集. 運動器の計測線・計測値ハンドブック. 東京: 南江堂; 2012 11. p.503-504.
山田 仁*, 箱﨑道之*. 長管骨病的骨折予測診断. In: 紺野愼一* 編集. 運動器の計測線・計測値ハンドブック. 東京: 南江堂; 2012 11. p.505.
山田 仁*, 箱﨑道之*. MRIで診断可能な組織や病態. In: 紺野愼一* 編集. 運動器の計測線・計測値ハンドブック. 東京: 南江堂; 2012 11. p.506.
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研究発表等
〔研究発表〕
HAKOZAKI, Michiyuki*; TAJINO, Takahiro*; KONNO, Shinichi*; KIKUCHI, Shinichi*; YAMADA, Hitoshi*; YANAGISAWA, Michiro; NISHIDA, Jun; NAGASAWA, Hiroyuki; TSUCHIYA, Takashi; OGOSE, Akira; ABE, Masafumi*; HOJO, Hiroshi*. Overexpression of cyclooxygenase-2 in malignant peripheral nerve sheath tumor and selective cyclooxygenase-2 inhibitor-induced apoptosis by activating caspase in human malignant peripheral nerve sheath tumor cells. 9th Asia Pacific Musculoskeletal Tumour Society Meeting 2012; 2012 09 08; Kuala Lumpur, Malaysia.
TAJINO, Takahiro*; KONNO, Shinichi*; YAMADA, Hitoshi*; HAKOZAKI, Michiyuki*. The treatment outcome of musculoskeletal tumors in the lower extremity reconstructed with heated (Pasteurized) auto-bone graft. 9th Asia Pacific Musculoskeletal Tumour Society Meeting 2012; 2012 09 07; Kuala Lumpur, Malaysia.
ENDO, Makoto; SETSU, Nokitaka; KOHASHI, Kenichi; YAMAMOTO, Hidetaka; TAMIYA, Sadafumi; MATSUDA, Shuichi; IWAMOTO, Yukihide; HAKOZAKI, Michiyuki*; IWASAKI, Hiroshi; ODA, Yoshinao. Clinicopathological and prognostic significance of Akt-mTOR and MAPK pathways and antitumor effect of mTOR inhibitor in malignant peripheral nerve sheath tumor (MPNST). 101st United States and Canadian Academy of Pathology Annual Meeting; 2012 03 19; Vancouver, Canada.
山田 仁*, 菊地臣一*, 田地野崇宏*, 箱﨑道之*, 紺野愼一*. 骨・軟部肉腫切除後の骨欠損に対する液体窒素処理自家骨移植による再建: 短期治療成績. 第45回日本整形外科学会骨・軟部腫瘍学術集会; 2012 07 14; 東京. 日本整形外科学会雑誌. 86(6):S864.
山田 仁*, 菊地臣一*, 田地野崇宏*, 箱﨑道之*, 紺野愼一*. 液体窒素処理によって膝蓋腱を温存し、膝伸展機構を再建した脛骨近位骨肉腫: 1例報告. 第45回日本整形外科学会骨・軟部腫瘍学術集会; 2012 07 14; 東京. 日本整形外科学会雑誌. 86(6):S874.
箱﨑道之*, 田地野崇宏*, 山田 仁*, 紺野愼一*, 北條 洋*, 渡邉一男*. 踵骨に生じた紡錘細胞血管腫: 1例報告. 第45回日本整形外科学会骨・軟部腫瘍学術集会; 2012 07 14; 東京. 日本整形外科学会雑誌. 86(6):S890.
田地野崇宏*, 菊地臣一*, 紺野愼一*, 山田 仁*, 箱﨑道之*, 菊田 敦*, 佐野秀樹*. 当科におけるJESS04レジメンを用いたEwing肉腫ファミリー腫瘍の治療成績. 第45回日本整形外科学会骨・軟部腫瘍学術集会; 2012 07 15; 東京. 日本整形外科学会雑誌. 86(6):S979.
田地野崇宏*, 紺野愼一*, 山田 仁*, 箱﨑道之*, 田﨑和洋*, 渡邉一男*. 同時期に両大腿部に異なる組織像を示す脂肪肉腫を生じた症例: 1例報告. 第45回日本整形外科学会骨・軟部腫瘍学術集会; 2012 07 15; 東京. 日本整形外科学会雑誌. 86(6):S994.
箱﨑道之*, 田地野崇宏*, 山田 仁*, 紺野愼一*, 田﨑和洋*, 渡邉一男*. 初診時に多発転移を有し集学的治療を行った悪性軟部骨化性線維粘液性腫瘍: 1例報告. 第45回日本整形外科学会骨・軟部腫瘍学術集会; 2012 07 15; 東京. 日本整形外科学会雑誌. 86(6):S998.
箱﨑道之*, 田地野崇宏*, 山田 仁*, 田﨑和洋*, 長谷川靖*, 渡邉一男*. 左上肢多発性軟部腫瘍. 第19回東北地区骨軟部腫瘍研究会; 2012 10 06; 盛岡.
箱﨑道之*, 福田宏成. 結晶誘発性手関節炎が原因と考えられたRS3PE症候群: 1例報告. 第17回運動器と痛み研究会; 2012 07 05; 福島.
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受託・共同研究・補助等実績一覧
| 年度 | 実施形態 | 研究テーマ | 補助金・資金制度名／種別 | 相手機関名 | 代表研究者 | 共同研究者一覧 |
|---|---|---|---|---|---|---|
| 平成24 | 国内共同研究 | 悪性末梢神経鞘腫における薬剤耐性機序の解析 | 鍋島 央 | 小田義直, 箱﨑道之* |
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